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低出生体重是否预示着学童患高血压和肥胖症?

Does low birth weight predict hypertension and obesity in schoolchildren?

机构信息

Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Ann Nutr Metab. 2013;63(1-2):69-76. doi: 10.1159/000351869. Epub 2013 Aug 8.

DOI:10.1159/000351869
PMID:23942014
Abstract

BACKGROUND

Birth weight appears to play a role in determining high blood pressure (BP) and obesity during childhood. The purpose of this study is to investigate the association between birth weight and later obesity and hypertension among 10- to 13-year-old schoolchildren.

METHODS

A total of 1,184 primary school students were selected from 20 randomized schools between 2011 and 2012 in Iran. Height, weight, waist circumference and BP were measured using standard instruments. Data were analyzed using stepwise regression and logistic regression models.

RESULTS

13.5% of children had a history of low birth weight. First-degree family history of obesity, excessive gestational weight gain and birth weight were significantly correlated with overweight/obesity and abdominal obesity (p = 0.001), whereas only birth weight was associated with high BP (p = 0.001). An inverse correlation was found between waist circumference and systolic/diastolic BP. The duration of breastfeeding in children with low birth weight was inversely correlated with obesity/overweight, abdominal obesity and hypertension.

CONCLUSION

The results suggests that birth weight is inversely associated with BP and more so with obesity and abdominal obesity. The duration of having been breastfed could have an influence on later hypertension, obesity and abdominal obesity. Further results are needed to test these correlations as well as diagnosing early life factors to prevent young adult overweight/obesity or hypertension.

摘要

背景

出生体重似乎在决定儿童期高血压(BP)和肥胖方面起着作用。本研究的目的是调查 10-13 岁学龄儿童的出生体重与以后肥胖和高血压之间的关系。

方法

2011 年至 2012 年期间,从伊朗 20 所随机学校中选择了 1184 名小学生。使用标准仪器测量身高、体重、腰围和血压。使用逐步回归和逻辑回归模型分析数据。

结果

13.5%的儿童有低出生体重史。一级肥胖家族史、过多的妊娠体重增加和出生体重与超重/肥胖和腹型肥胖显著相关(p=0.001),而只有出生体重与高血压相关(p=0.001)。腰围与收缩压/舒张压呈负相关。低出生体重儿童的母乳喂养时间与肥胖/超重、腹型肥胖和高血压呈负相关。

结论

结果表明,出生体重与血压呈负相关,与肥胖和腹型肥胖的相关性更强。母乳喂养的时间长短可能会对以后的高血压、肥胖和腹型肥胖产生影响。需要进一步的结果来检验这些相关性以及诊断早期生活因素,以预防年轻成年人超重/肥胖或高血压。

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