aDepartment of Biomedical Sciences bProgram in Neuroscience, Florida State University College of Medicine, Tallahassee, Florida, USA.
Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):708-11. doi: 10.1097/MCO.0b013e328364f39c.
In light of the recent recognition that even mild forms of traumatic brain injury (TBI) can lead to long-term cognitive and behavioral deficits, this review examines recent data on the neuroprotective and neurotoxic roles of zinc after brain injury.
Data show that treatment using dietary and parenteral zinc supplementation can reduce TBI-associated depression and improve cognitive function, specifically spatial learning and memory. However, excessive release of free zinc, particularly in the hippocampus associated with acute injury, can lead to increases in protein ubiquitination and neuronal death.
This work shows the need for future research to clarify the potentially contradictory roles of zinc in the hippocampus and define the clinical use of zinc as a treatment following brain injury in humans. This is particularly important given the finding that zinc may reduce TBI-associated depression, a common and difficult outcome to treat in all forms of TBI.
鉴于最近人们认识到即使是轻度创伤性脑损伤 (TBI) 也会导致长期认知和行为缺陷，本综述检查了脑损伤后锌的神经保护和神经毒性作用的最新数据。
数据表明，使用饮食和肠外锌补充治疗可以减少与 TBI 相关的抑郁并改善认知功能，特别是空间学习和记忆。然而，游离锌的过度释放，特别是与急性损伤相关的海马体中的释放，会导致蛋白质泛素化和神经元死亡增加。
这项工作表明需要进一步研究来阐明锌在海马体中的潜在矛盾作用，并确定锌在人类脑损伤后的临床应用。鉴于锌可能会降低 TBI 相关的抑郁，这是所有类型 TBI 中常见且难以治疗的结果，这一点尤为重要。
