Staples J J, Robinson R A, Wen B C, Hussey D H
Department of Radiology, University of Iowa College of Medicine, Iowa City 52242.
Int J Radiat Oncol Biol Phys. 1990 Aug;19(2):445-51. doi: 10.1016/0360-3016(90)90556-y.
Between 1955 and 1987, 15 patients with hemangiopericytomas were seen at the University of Iowa Hospitals and Clinics. Twelve of these were thought to have localized tumors and three had metastatic disease at diagnosis. Seven of the 12 patients with localized disease were treated with surgery alone, four were treated with surgery and postoperative radiation therapy, and one was treated with surgery and chemotherapy. Only one of the seven patients initially treated with surgery alone has remained continuously free of disease, although two others were salvaged with radiation therapy. In contrast, all four patients initially treated with surgery and postoperative radiation therapy have remained alive with no evidence of disease in spite of the fact that three of these patients had gross residual tumor at the time of irradiation. Ten patients received radiation therapy at some stage of their management. Local tumor control was achieved at all sites receiving greater than 5500 cGy. Six patients received chemotherapy sometime during the course of their management, although no complete or partial responses were observed. In this small series, mitotic activity was not an accurate predictor of biologic behavior.
1955年至1987年间，爱荷华大学医院及诊所共收治了15例血管外皮细胞瘤患者。其中12例被认为患有局限性肿瘤，3例在诊断时已有转移性疾病。12例局限性疾病患者中，7例仅接受了手术治疗，4例接受了手术及术后放射治疗，1例接受了手术及化疗。最初仅接受手术治疗的7例患者中，只有1例一直无疾病复发，尽管另外2例通过放射治疗得以挽救。相比之下，最初接受手术及术后放射治疗的4例患者均存活，且无疾病迹象，尽管其中3例患者在放疗时仍有肉眼可见的残留肿瘤。10例患者在治疗的某个阶段接受了放射治疗。所有接受超过5500 cGy照射的部位均实现了局部肿瘤控制。6例患者在治疗过程中的某个时间接受了化疗，尽管未观察到完全或部分缓解。在这个小样本系列中，有丝分裂活性并不是生物学行为的准确预测指标。
