Kaur Kulmeet, Sikri Poonam
Department of Periodontology and Oral Implantology, B.J.S. Dental College, Ludhiana, India.
Dent Res J (Isfahan). 2013 Mar;10(2):238-46. doi: 10.4103/1735-3327.113359.
Successful prevention and treatment of periodontal disease are contingent on effective control of periodontopathic microbiota based on the premise of periodontal disease being infectious disorders. An anti-microbial agent, i.e., doxycycline has been incorporated into the allograft to control infection and facilitate healing during and after periodontal therapy.
Using a split-mouth design, 15 patients showing clinical evidence of almost identical bilateral infrabony defects requiring bone grafting procedures were randomly selected. In each patient, infrabony defects on one side were designated as Group A (control group) and infrabony defects of the contralateral side of the same arch were designated as Group B (test group). Clinical assessment of probing pocket depth and attachment level and radiographic evaluation of the defect depth was done pre-operatively and at 12-week and 24-week post-operatively. The relative efficacy of the two treatment modalities was evaluated using paired Student's t-test and the comparative evaluation between the two groups over the 3 time intervals was done using independent Student's t-test.
Both the groups exhibited a highly significant reduction in probing depth and gain in clinical attachment level (CAL) and a linear bone fill at the end of 12 and 24 weeks. Comparative evaluation showed a statistically significant gain in bone fill in Group B as compared to Group A, whereas a non-significant reduction in probing depth and gain in CALs between the two groups at the end of 24 weeks (whereas mean reduction in probing depth and gain in CAL were also greater in Group B but the difference was statistically non-significant).
The increase in linear bone fill in Group B signifies the role of doxycycline in augmenting regenerative potential of allograft by combating residual infection and through host modulation.
牙周病作为感染性疾病，其成功的预防和治疗取决于对牙周致病微生物群的有效控制。一种抗菌剂，即强力霉素已被纳入同种异体移植物中，以控制感染并促进牙周治疗期间及之后的愈合。
采用分口设计，随机选择15例有几乎相同双侧骨下袋缺损且需要进行骨移植手术的临床证据的患者。在每位患者中，一侧的骨下袋缺损被指定为A组（对照组），同一牙弓对侧的骨下袋缺损被指定为B组（试验组）。术前以及术后12周和24周进行探诊深度和附着水平的临床评估以及缺损深度的影像学评估。使用配对t检验评估两种治疗方式的相对疗效，使用独立t检验对两组在3个时间间隔内进行比较评估。
两组在12周和24周结束时均表现出探诊深度显著降低、临床附着水平（CAL）增加以及线性骨填充。比较评估显示，与A组相比，B组的骨填充有统计学显著增加，而在24周结束时两组之间的探诊深度降低和CAL增加无统计学意义（尽管B组的探诊深度平均降低和CAL增加也更大，但差异无统计学意义）。
B组线性骨填充的增加表明强力霉素通过对抗残余感染和宿主调节增强同种异体移植物再生潜力的作用。
