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临床综述13:格雷夫斯眼病的诊断与管理

Clinical review 13: Diagnosis and management of Graves' ophthalmopathy.

作者信息

Bahn R S, Garrity J A, Gorman C A

机构信息

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.

出版信息

J Clin Endocrinol Metab. 1990 Sep;71(3):559-63. doi: 10.1210/jcem-71-3-559.

DOI:10.1210/jcem-71-3-559
PMID:2394769
Abstract

Although Graves ophthalmopathy is a potentially sight threatening and disfiguring condition that can be frightening for the patient to experience, there are effective means of management. At the present time, treatment is based on the relief of excessive intraorbital pressures and is accomplished either by shrinking the orbital contents or by expanding the orbital volume. The most effective treatment modality or combination of modalities is an area of controversy. However, it must be remembered that the approach to management undertaken should be finely tuned to the needs of the particular individual afflicted with the condition. Perhaps with a greater understanding of pathophysiology, more reliable and effective treatments, based on specific pathophysiological mechanisms, may be developed. In addition, tests to reliably predict those patients most likely to progress in their disease might be developed, allowing preventive measures to be taken.

摘要

尽管格雷夫斯眼病是一种可能威胁视力且有损容貌的疾病,患者经历起来可能会感到恐惧,但仍有有效的治疗方法。目前,治疗基于减轻眶内压力过高,可通过缩小眶内容物或扩大眶容积来实现。最有效的治疗方式或多种方式的组合存在争议。然而,必须记住,所采取的治疗方法应根据患病个体的具体需求进行微调。或许随着对病理生理学有更深入的了解,基于特定病理生理机制的更可靠、有效的治疗方法可能会被研发出来。此外,可能会研发出可靠预测哪些患者病情最有可能进展的检测方法,从而能够采取预防措施。

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引用本文的文献

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Thyroid associated ophthalmopathy - a review.甲状腺相关性眼病——综述
Malays Fam Physician. 2009 Apr 30;4(1):8-14. eCollection 2009.
2
Orbital fibroblast chemokine modulation: effects of dexamethasone and cyclosporin A.眼眶成纤维细胞趋化因子调节:地塞米松和环孢素A的作用
Br J Ophthalmol. 1998 Mar;82(3):318-22. doi: 10.1136/bjo.82.3.318.
3
Graves' ophthalmopathy.格雷夫斯眼病
West J Med. 1993 Jun;158(6):591-5.
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Soluble intercellular adhesion molecule-1 (sICAM-1) in sera of patients with Graves' ophthalmopathy and thyroid diseases.格雷夫斯眼病和甲状腺疾病患者血清中的可溶性细胞间粘附分子-1(sICAM-1)
Clin Exp Immunol. 1993 May;92(2):296-302. doi: 10.1111/j.1365-2249.1993.tb03395.x.
5
Elevated expression in situ of selectin and immunoglobulin superfamily type adhesion molecules in retroocular connective tissues from patients with Graves' ophthalmopathy.格雷夫斯眼病患者眼后结缔组织中选择素和免疫球蛋白超家族型黏附分子的原位表达升高。
Clin Exp Immunol. 1993 Mar;91(3):381-9. doi: 10.1111/j.1365-2249.1993.tb05913.x.
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Soluble IL-2 receptor levels in patients with Graves' ophthalmopathy.格雷夫斯眼病患者的可溶性白细胞介素-2受体水平
Clin Exp Immunol. 1992 Jun;88(3):405-9. doi: 10.1111/j.1365-2249.1992.tb06462.x.