University of Michigan, Department of Chemistry, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
Org Lett. 2012 Aug 17;14(16):4094-7. doi: 10.1021/ol301739f. Epub 2012 Jul 30.
The palladium-catalyzed C-H fluorination of 8-methylquinoline derivatives with nucleophilic fluoride is reported. This transformation involves the use of AgF as the fluoride source in combination with a hypervalent iodine oxidant. Both the scope and mechanism of the reaction are discussed.
报道了钯催化的 8-甲基喹啉衍生物与亲核氟化物的 C-H 氟化反应。该转化涉及使用 AgF 作为氟源,并结合高价碘氧化剂。讨论了反应的范围和机理。