社会经济地位与肺癌：解析基因混合的作用。
Socioeconomic status and lung cancer: unraveling the contribution of genetic admixture.
机构信息
At the time of the study, Melinda C. Aldrich was with the Division of Epidemiology, School of Public Health, University of California, Berkeley. Steve Selvin is with the Division of Biostatistics, School of Public Health, University of California, Berkeley. Margaret R. Wrensch, Helen M. Hansen, and John K. Wiencke are with the Department of Neurologic Surgery, University of California, San Francisco. Jennette D. Sison was with the Department of Neurologic Surgery, University of California, San Francisco. Charles P. Quesenberry Jr, is with the Division of Research, Kaiser Permanente, Oakland, CA. Michael F. Seldin is with the Departments of Biological Chemistry and Medicine, University of California, Davis. Lisa F. Barcellos and Patricia A. Buffler are with the Division of Epidemiology, School of Public Health, University of California, Berkeley.
出版信息
Am J Public Health. 2013 Oct;103(10):e73-80. doi: 10.2105/AJPH.2013.301370. Epub 2013 Aug 15.
OBJECTIVES
We examined the relationship between genetic ancestry, socioeconomic status (SES), and lung cancer among African Americans and Latinos.
METHODS
We evaluated SES and genetic ancestry in a Northern California lung cancer case-control study (1998-2003) of African Americans and Latinos. Lung cancer case and control participants were frequency matched on age, gender, and race/ethnicity. We assessed case-control differences in individual admixture proportions using the 2-sample t test and analysis of covariance. Logistic regression models examined associations among genetic ancestry, socioeconomic characteristics, and lung cancer.
RESULTS
Decreased Amerindian ancestry was associated with higher education among Latino control participants and greater African ancestry was associated with decreased education among African lung cancer case participants. Education was associated with lung cancer among both Latinos and African Americans, independent of smoking, ancestry, age, and gender. Genetic ancestry was not associated with lung cancer among African Americans.
CONCLUSIONS
Findings suggest that socioeconomic factors may have a greater impact than genetic ancestry on lung cancer among African Americans. The genetic heterogeneity and recent dynamic migration and acculturation of Latinos complicate recruitment; thus, epidemiological analyses and findings should be interpreted cautiously.
目的
我们研究了非裔美国人和拉丁裔人群中遗传背景、社会经济地位（SES）和肺癌之间的关系。
方法
我们在加利福尼亚北部的一项非裔美国人和拉丁裔人群的肺癌病例对照研究（1998-2003 年）中评估了 SES 和遗传背景。肺癌病例和对照参与者按照年龄、性别和种族/族裔进行频数匹配。我们使用两样本 t 检验和协方差分析评估了个体混合比例的病例对照差异。逻辑回归模型检验了遗传背景、社会经济特征与肺癌之间的关联。
结果
拉丁裔对照组中，较低的美洲印第安人遗传背景与较高的教育程度相关，而非洲裔肺癌病例组中，较高的非洲遗传背景与较低的教育程度相关。教育程度与非裔美国人和拉丁裔人群的肺癌均相关，独立于吸烟、遗传背景、年龄和性别。遗传背景与非裔美国人的肺癌无关。
结论
研究结果表明，社会经济因素对非裔美国人的肺癌可能比遗传背景有更大的影响。拉丁裔人群的遗传异质性和近期的动态迁移和文化融合增加了招募的复杂性；因此，应谨慎解释流行病学分析和结果。
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