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1型糖尿病发病后新冠病毒感染引发儿童硬皮病综合征:一例报告

Onset of Type I Diabetes Followed by Scleroderma Syndrome in a Child After the COVID-19: A Case Report.

作者信息

Burlaka Ievgeniia, Mityuryayeva Inga, Sevastiian Olena, Kachula Ivanna

机构信息

Bogomolets National Medical University, Kyiv, Ukraine.

出版信息

Glob Pediatr Health. 2024 Aug 30;11:2333794X241276356. doi: 10.1177/2333794X241276356. eCollection 2024.

Abstract

Morphea, is a chronic inflammatory disease of the dermis and subcutaneous tissue. Research has indicated a connection between morphea and Type I Diabetes (T1D). COVID-19 can cause autoimmune diseases like scleroderma, T1D, systemic lupus erythematosus, and others. A 12-year-old girl with type 1 diabetes who was on insulin therapy was brought into the clinic for a metabolic evaluation. The patient had induration, skin hardness, and cutaneous erythema upon inspection. The onset of T1D was following a mild COVID-19 infection. Signs of morphea merged 3 months after the onset of T1D. Known as "long-term COVID," this sickness phase that follows the acute stage of COVID-19 is most likely the result of autoimmune activation. As this patient under evaluation reveals, COVID-19 has been demonstrated in the literature to cause the production of autoantibodies and to either cause or worsen autoimmune disorders in people who have a genetic susceptibility.

摘要

硬斑病是一种真皮和皮下组织的慢性炎症性疾病。研究表明硬斑病与1型糖尿病(T1D)之间存在关联。新冠病毒(COVID-19)可引发硬皮病、1型糖尿病、系统性红斑狼疮等自身免疫性疾病。一名接受胰岛素治疗的12岁1型糖尿病女孩因代谢评估被送至诊所。检查发现该患者有硬结、皮肤硬化和皮肤红斑。1型糖尿病的发病发生在轻度新冠病毒感染之后。硬斑病症状在1型糖尿病发病3个月后出现。这种在新冠病毒急性期之后出现的疾病阶段被称为“长期新冠”,很可能是自身免疫激活的结果。正如该接受评估的患者所示,文献已证明新冠病毒会导致自身抗体产生,并在有遗传易感性的人群中引发或加重自身免疫性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0243/11365024/dc14054f6e51/10.1177_2333794X241276356-fig1.jpg

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