Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Child Abuse Negl. 2013 Nov;37(11):1021-9. doi: 10.1016/j.chiabu.2013.07.008. Epub 2013 Aug 12.
The experience of childhood maltreatment is related to an increased risk of developing a variety of psychiatric disorders, as well as a change in the structure of the brain. However, not much is known about the neurobiological basis of resilience to childhood maltreatment. This study aims to identify resting-state functional connectivity (RSFC) patterns specific for resilience to childhood maltreatment, focusing on the default mode and salience network and networks seeded from the amygdala and left dorsomedial prefrontal cortex. Resting-state functional MRI scans were obtained in 33 individuals. Seeds in the bilateral amygdala, the dorsal anterior cingulate cortex (dACC), the posterior cingulate cortex and the left dorsomedial prefrontal cortex were defined and used to examine whether resilient individuals differed from vulnerable individuals and healthy controls in RSFC with other brain regions. Within the salience network, the resilient group was associated with increased RSFC between the left dACC and a region containing the bilateral lingual gyrus and the occipital fusiform gyrus compared to both the vulnerable group and the healthy controls. In this study, we found RSFC patterns specific for resilient individuals. Regions that are implicated are related on a functional level to declarative memory and the processing of emotional stimuli.
童年期虐待经历与多种精神障碍的发病风险增加以及大脑结构的改变有关。然而，对于童年期虐待的韧性的神经生物学基础知之甚少。本研究旨在确定针对童年期虐待的韧性的静息态功能连接（RSFC）模式，重点关注默认模式和突显网络，以及从杏仁核和左背内侧前额叶皮层种子的网络。对 33 名个体进行了静息态功能磁共振成像扫描。定义了双侧杏仁核、背侧前扣带皮层（dACC）、后扣带皮层和左背内侧前额叶皮层的种子，并用于检查韧性个体与易受伤害个体和健康对照组在与其他大脑区域的 RSFC 方面是否存在差异。在突显网络中，与易受伤害组和健康对照组相比，韧性组的左 dACC 与包含双侧舌回和枕梭状回的区域之间的 RSFC 增加。在这项研究中，我们发现了针对韧性个体的 RSFC 模式。所涉及的区域在功能上与陈述性记忆和情绪刺激的处理有关。
