Setroikromo Santoucha N W, van der Werff Steven J A, Smit Annika S, Vermetten Eric, Van Der Wee Nic J A
Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.
Leiden Institute for Brain and Cognition, Leiden, Netherlands.
Front Behav Neurosci. 2022 Jul 27;16:919327. doi: 10.3389/fnbeh.2022.919327. eCollection 2022.
Insights into the neurobiological basis of resilience can have important implications for the prevention and treatment of stress-related disorders, especially in populations that are subjected to high-stress environments. Evaluating large-scale resting-state networks (RSNs) can provide information regarding resilient specific brain function which may be useful in understanding resilience. This study aimed to explore functional connectivity patterns specific for (high) resilience in Dutch policemen after exposure to multiple work-related traumatic events. We investigated resting-state functional connectivity (RSFC) of the salience network (SN), limbic network, and the default-mode network (DMN).
Resting-state functional MRI scans were obtained from trauma-exposed executive personnel of the Dutch police force and non-trauma-exposed recruits from the police academy. Participants were divided into three groups: a resilient group ( = 31; trauma exposure; no psychopathology), a vulnerable group ( = 32; trauma exposure, psychopathology), and a control group ( = 19; no trauma exposure, no psychopathology). RSFC of the three networks of interest was compared between these groups, using an independent component analysis and a dual regression approach.
We found decreased resilience-specific positive RSFC of the salience network with several prefrontal regions. The DMN and limbic network RFSC did not show resilience-specific patterns.
This study shows a differential RSFC specific for resilient police officers. This differential RSFC may be related to a greater capacity for internal-focused thought and interoceptive awareness, allowing more effective higher-order responses to stress in highly resilient individuals.
深入了解复原力的神经生物学基础对于预防和治疗与压力相关的疾病具有重要意义,特别是在处于高压力环境的人群中。评估大规模静息态网络(RSN)可以提供有关特定于复原力的大脑功能的信息,这可能有助于理解复原力。本研究旨在探讨荷兰警察在经历多次与工作相关的创伤事件后,(高)复原力所特有的功能连接模式。我们研究了突显网络(SN)、边缘系统网络和默认模式网络(DMN)的静息态功能连接(RSFC)。
对荷兰警察部队中经历过创伤的行政人员和警察学院未经历过创伤的新兵进行静息态功能磁共振成像扫描。参与者分为三组:复原力组(n = 31;经历过创伤;无精神病理学症状)、易损组(n = 32;经历过创伤,有精神病理学症状)和对照组(n = 19;未经历过创伤,无精神病理学症状)。使用独立成分分析和双回归方法比较了这三组之间感兴趣的三个网络的RSFC。
我们发现突显网络与几个前额叶区域之间的复原力特异性正RSFC降低。DMN和边缘系统网络的RFSC未显示出复原力特异性模式。
本研究显示了特定于有复原力警察的差异性RSFC。这种差异性RSFC可能与更强大的内聚焦思维和内感受性觉知能力有关,从而使高复原力个体能够更有效地对应激做出高阶反应。