Jansen J H, Arnesen K
Department of Pathology, Norweigan College of Veterinary Medicine, Oslo.
J Comp Pathol. 1990 Jul;103(1):79-84. doi: 10.1016/s0021-9975(08)80137-5.
Severe oxalate nephropathy with end-stage kidney lesions was found in two pups of a litter of three Tibetan Spaniels. This histopathological finding strongly suggests a primary hyperoxaluria since there was no exposure to agents capable of producing secondary hyperoxaluria. Primary hyperoxaluria has not been reported as a spontaneous disease in the dog, although it is a well-known, but rare, inherited metabolic disease of man.
在一窝三只藏獒幼犬中，有两只出现了伴有终末期肾脏病变的严重草酸盐肾病。这一组织病理学发现强烈提示原发性高草酸尿症，因为这些幼犬未接触过可导致继发性高草酸尿症的因素。原发性高草酸尿症在犬类中尚未被报道为自发性疾病，尽管它在人类中是一种已知但罕见的遗传性代谢疾病。
