无柄果熊果酸和去氢无柄果熊果酸，两种来自无柄果的新三萜。
Uncarilic acid and secouncarilic acid, two new triterpenoids from Uucaria sessilifructus.
机构信息
Key Laboratory of Tropical Plant Resource Science, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, Yunnan, China.
出版信息
Molecules. 2013 Aug 14;18(8):9727-34. doi: 10.3390/molecules18089727.
Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.
从绒毛钩藤的钩和茎中分离得到了两种新的化合物，即 6-酮齐墩果酸型三萜乌苏酸和其 5,6-裂环三萜衍生物 secouncarilic 酸，以及 7 种已知的乌苏烷型三萜。乌苏酸是第二种报道的 6-酮齐墩果酸型三萜，而 secouncarilic 酸是第一个齐墩果酸型 5,6-裂环三萜。还提出了从乌苏酸到 secouncarilic 酸的可能生物合成途径。评估了所有 9 种化合物对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮产生的抑制活性。
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