Key Laboratory of Tropical Plant Resource Science, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, Yunnan, China.
Molecules. 2013 Aug 14;18(8):9727-34. doi: 10.3390/molecules18089727.
Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.
从绒毛钩藤的钩和茎中分离得到了两种新的化合物，即 6-酮齐墩果酸型三萜乌苏酸和其 5,6-裂环三萜衍生物 secouncarilic 酸，以及 7 种已知的乌苏烷型三萜。乌苏酸是第二种报道的 6-酮齐墩果酸型三萜，而 secouncarilic 酸是第一个齐墩果酸型 5,6-裂环三萜。还提出了从乌苏酸到 secouncarilic 酸的可能生物合成途径。评估了所有 9 种化合物对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮产生的抑制活性。
