一种来自红旱莲的具有不寻常烯二酮部分的新型3,4-裂齐墩果烷型三萜类化合物。

A new 3,4-seco-oleanane-type triterpenoid with an unusual enedione moiety from Hypericum ascyron.

作者信息

Chen Chunmei, Wei Guangzheng, Zhu Hucheng, Guo Yi, Li Xiao-Nian, Zhang Jinwen, Liu Yanfei, Yao Guangmin, Luo Zengwei, Xue Yongbo, Zhang Yonghui

机构信息

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.

出版信息

Fitoterapia. 2015 Jun;103:227-30. doi: 10.1016/j.fitote.2015.04.009. Epub 2015 Apr 12.

DOI:10.1016/j.fitote.2015.04.009

PMID:25870936

Abstract

A novel 3,4-seco-oleanane-type triterpenoid named 3,4-seco-olean-13(18)-ene-12,19-dione-3-oic acid (1), bearing an unusual enedione moiety, was isolated from the aerial parts of Hypericum ascyron, together with a known feiedelane-type triterpenoid friedelin (2). The structure of 1 with absolute configuration was elucidated on the basis of spectroscopic methods and a single-crystal X-ray diffraction analysis.

摘要

从红旱莲地上部分分离得到一种新型的3,4-断齐墩果烷型三萜类化合物，即3,4-断齐墩果-13(18)-烯-12,19-二酮-3-酸（1），其带有一个不寻常的烯二酮部分，同时还得到一种已知的费德烷型三萜类化合物木栓酮（2）。基于光谱方法和单晶X射线衍射分析阐明了化合物1的结构及其绝对构型。