通过末端半胱氨酸与 2-氰基苯并噻唑之间的生物相容性反应实现生物分子的位点特异性固定。
Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole.
机构信息
Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
出版信息
Chem Commun (Camb). 2013 Oct 7;49(77):8644-6. doi: 10.1039/c3cc43566k.
PMID:23948853
Abstract
We report herein a new site-specific microarray immobilization method based on a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole (CBT). This immobilization strategy has been successfully applied to anchor small molecules, peptides and proteins onto microarrays.
摘要
我们在此报告了一种新的基于末端半胱氨酸与 2-氰基苯并噻唑（CBT）之间生物相容性反应的定点微阵列固定方法。这种固定策略已成功应用于将小分子、肽和蛋白质固定在微阵列上。
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