Faculty of Medicine and Life Sciences, Rehabilitation Research Centre, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
NeuroRehabilitation. 2013;33(1):139-46. doi: 10.3233/NRE-130938.
To explore the etiology of exercise intolerance in patients with MS, it is analyzed whether a disturbed cardiac autonomic control could be observed during exercise testing in patients with MS, and is related to exercise tolerance.
From 26 MS patients and 15 healthy subjects, exercise-onset (first 20 and 60 seconds) and -offset (1-minute recovery) HR change was determined during a 6-minute constant-load exercise bout on bike. Blood lactate, HR, oxygen uptake, expiratory volume and perceived exertion were assessed during exercise, and compared between groups. In 15 MS patients, a 6-min walking test was executed.
Twenty-second exercise-onset HR increase was significantly smaller in MS patients (14 ± 7 bts/min) vs. healthy subjects (20 ± 8 bts/min, p < 0.05), and independently related to MS and age in total group (p < 0.05). Sixty-second exercise-onset and -offset HR changes were not different between groups, nor independently related to MS presence (p > 0.05). A significant correlation was found between 20-second exercise-onset HR increase and walking capacity in MS patients (r = 0.64, p < 0.01).
In MS patients, the early increase in heart rate during endurance exercise is significantly slowed, indicating a disturbed cardiac autonomic control, and is related to exercise tolerance.
探讨多发性硬化症（MS）患者运动不耐受的病因，分析运动试验中是否观察到心脏自主神经控制紊乱，以及其与运动耐力的关系。
对 26 例 MS 患者和 15 名健康对照者，在自行车上进行 6 分钟恒负荷运动试验期间，测定运动起始（前 20 秒和 60 秒）和运动结束（1 分钟恢复期）时的 HR 变化。在运动过程中评估血乳酸、HR、摄氧量、呼气量和感知用力程度，并在组间进行比较。对 15 例 MS 患者进行 6 分钟步行试验。
MS 患者的第 20 秒运动起始 HR 增加明显小于健康对照组（14 ± 7 bts/min 比 20 ± 8 bts/min，p < 0.05），并且与总组中的 MS 和年龄独立相关（p < 0.05）。60 秒运动起始和结束时的 HR 变化在两组之间无差异，也与 MS 的存在无关（p > 0.05）。MS 患者的第 20 秒运动起始 HR 增加与步行能力呈显著相关（r = 0.64，p < 0.01）。
在 MS 患者中，耐力运动期间心率的早期增加明显减慢，表明心脏自主神经控制紊乱，与运动耐力相关。
