Hasselt University, Diepenbeek, Belgium.
Neurorehabil Neural Repair. 2013 Jan;27(1):87-95. doi: 10.1177/1545968312451916. Epub 2012 Jul 10.
Low physical activity levels in persons with multiple sclerosis (MS) may reduce skeletal muscle oxidative capacity. Rehabilitation strategies might be altered by a measure of capacity that did not require invasive techniques or maximal exercise testing. For this purpose, we measured exercise onset and offset oxygen uptake (Vo(2)) kinetics during endurance exercise.
This study compared exercise-onset and -offset Vo(2) kinetics in mildly affected persons with MS with healthy matched participants.
From 38 MS patients who had a mean Expanded Disability Status Scale of 3.1 and 16 healthy participants, exercise-onset and -offset Vo(2) kinetics (mean response time [MRT]) were determined during two 6-minute submaximal bouts of exercise separated by a 6-minute recovery interval. Blood lactate, heart rate, expiratory volume, and Borg ratings of perceived exertion were assessed during exercise and compared between groups. Relationships between clinical characteristics and MRT were assessed.
During exercise, blood lactate, heart rate, and expiratory volume did not differ between groups (P > .05), but exercise-onset MRT was significantly slower in MS versus healthy participants (P = .007). Exercise-onset MRT was independently related to having MS (P = .02). Exercise-offset MRT was not different between groups or was independently related to having MS (P > .05). No independent relationships between clinical characteristics of MS and exercise-onset or -offset MRT were found.
Exercise-onset Vo(2) kinetics during submaximal endurance exercise are significantly slowed in mildly disabled persons with MS, suggesting low skeletal muscle oxidative capacity. Using mean response time testing, rehabilitation interventions for this reduction in exercise capacity can be assessed and targeted.
多发性硬化症（MS）患者的低体力活动水平可能会降低骨骼肌的氧化能力。如果有一种不需要侵入性技术或最大运动测试的能力测量方法，那么康复策略可能会发生改变。为此，我们测量了耐力运动期间运动起始和结束时的摄氧量（Vo(2)）动力学。
本研究比较了轻度 MS 患者与健康匹配参与者的运动起始和结束时的 Vo(2)动力学。
从平均扩展残疾状况量表评分为 3.1 的 38 名 MS 患者和 16 名健康参与者中，在 6 分钟恢复期后进行了两次 6 分钟次最大运动试验，确定了运动起始和结束时的 Vo(2)动力学（平均反应时间 [MRT]）。在运动期间评估了血乳酸、心率、呼气量和 Borg 感知用力评分，并比较了两组之间的差异。评估了临床特征与 MRT 之间的关系。
在运动过程中，两组之间的血乳酸、心率和呼气量没有差异（P >.05），但 MS 患者的运动起始 MRT 明显较慢（P =.007）。运动起始 MRT 与患有 MS 独立相关（P =.02）。两组之间的运动结束 MRT 没有差异，也与患有 MS 无关（P >.05）。未发现 MS 临床特征与运动起始或结束 MRT 之间存在独立关系。
在轻度残疾的 MS 患者中，亚最大耐力运动期间的运动起始 Vo(2)动力学明显减慢，提示骨骼肌氧化能力低下。使用平均反应时间测试，可以评估和针对这种运动能力下降的康复干预措施。
