Department of Applied Physiology and Kinesiology and Center for Movement Disorders & Neurorestoration, University of Florida, Gainesville, FL, USA.
NeuroRehabilitation. 2013;33(2):305-12. doi: 10.3233/NRE-130960.
High frequency stimulation (HFS) of the subthalamic nucleus is one of the most effective treatments for advanced Parkinson's disease (PD). HFS has provided beneficial improvements in the cardinal features of PD, but has not been proven as effective for addressing the axial predominant levodopa resistant symptoms, such as speech disturbances, gait disturbances, and postural instability. Recent studies have suggested that changes in stimulation parameters may influence differing PD symptoms.
The purpose of this study was to compare the effects of low frequency stimulation (LFS) versus HFS on the Unified Parkinson's Disease Rating Scale (UPDRS), gait, balance, and verbal fluency.
Eight tremor dominant and nine non-tremor dominant participants with bilateral deep brain stimulation of the subthalamic nucleus were tested off stimulation, during LFS, and during HFS.
Results revealed that HFS significantly reduced UPDRS tremor score in the tremor dominant group; however no differences emerged within the non-tremor dominant group. No differences between groups or stimulation conditions were found for gait, balance, and verbal fluency measures.
These results may suggest that HFS is better than LFS for reducing tremor in tremor dominant patients. However, patients with mild or no tremor show no acute differences in benefit from LFS as compared to HFS.
高频刺激（HFS）丘脑底核是治疗晚期帕金森病（PD）最有效的方法之一。HFS 已为 PD 的主要特征提供了有益的改善，但尚未被证明对解决轴向为主的抗左旋多巴症状（如言语障碍、步态障碍和姿势不稳定）有效。最近的研究表明，刺激参数的变化可能会影响不同的 PD 症状。
本研究旨在比较低频刺激（LFS）与 HFS 对统一帕金森病评定量表（UPDRS）、步态、平衡和言语流畅性的影响。
对 8 名震颤为主和 9 名非震颤为主的双侧丘脑底核深部脑刺激患者进行测试，分别为刺激关闭时、LFS 时和 HFS 时。
结果表明，HFS 可显著降低震颤为主组的 UPDRS 震颤评分；然而，在非震颤为主组中未出现差异。在步态、平衡和言语流畅性测量方面，组间或刺激条件间无差异。
这些结果可能表明，HFS 比 LFS 更能减少震颤为主患者的震颤。然而，与 HFS 相比，轻度震颤或无震颤的患者在 LFS 中没有急性获益差异。
