Department of Ophthalmology, Ehime University School of Medicine, Ehime, Japan.
JAMA Ophthalmol. 2013 Oct;131(10):1331-8. doi: 10.1001/jamaophthalmol.2013.4503.
A validated questionnaire that assesses symptoms and the effect of dry eye disease (DED) on the patient's daily life is needed to evaluate the condition.
To develop and validate the Dry Eye-Related Quality-of-Life Score (DEQS) questionnaire in Japan.
DESIGN, SETTING, AND PARTICIPANTS: Development and evaluation of the DEQS questionnaire were conducted in 4 phases: (1) item generation, (2) pilot study to assess content and face validity, (3) preliminary psychometric validation study to examine factor structure and reduce the number of items, and (4) final psychometric validation with 224 participants (203 with DED and 21 serving as controls). Participants completed the DEQS questionnaire, the Short Form-8, and the National Eye Institute Visual Function Questionnaire-25. To evaluate reproducibility and responsiveness, individuals with DED completed the DEQS questionnaire twice.
Internal consistency, reproducibility, discriminant validity, concurrent validity, and responsiveness.
Items were generated from a literature review, and 35 items were selected for the draft version. In the pilot study, 11 items were deleted; furthermore, 9 items were deleted based on the results of item analysis and factor analysis in the preliminary validation study. The final 15-item DEQS questionnaire consisted of an Overall Summary scale and 2 multi-item subscales: Impact on Daily Life and Bothersome Ocular Symptoms. The psychometric analysis revealed that the DEQS questionnaire has good internal consistency, test-retest reliability, discriminant validity, and responsiveness to change. The DEQS questionnaire correlated well with the mental component of the Short Form-8 and showed strong correlations with 4 subscales (Ocular Pain, Near Vision, Distance Vision, and Mental Health) of the National Eye Institute Visual Function Questionnaire-25.
The DEQS questionnaire is valid and reliable for evaluating the multifaceted effect of DED on the patient's daily life, including mental health, and it can be used easily in routine clinical practice.
需要一种经过验证的问卷来评估干眼症 (DED) 患者的症状和疾病对日常生活的影响。
在日本开发和验证干眼相关生活质量评分 (DEQS) 问卷。
设计、设置和参与者：DEQS 问卷的开发和评估分为 4 个阶段进行：(1)项目生成，(2)评估内容和表面有效性的试点研究，(3)初步心理测量验证研究，以检查结构和减少项目数量，以及 (4) 对 224 名参与者（203 名患有 DED，21 名作为对照）进行最终心理测量验证。参与者完成了 DEQS 问卷、简短形式-8 和国家眼科研究所视觉功能问卷-25。为了评估可重复性和反应性，患有 DED 的个体两次完成了 DEQS 问卷。
内部一致性、可重复性、判别有效性、同时有效性和反应性。
从文献综述中生成项目，并选择了 35 个项目作为草案。在试点研究中，删除了 11 个项目；此外，根据初步验证研究中的项目分析和因素分析结果，删除了 9 个项目。最终的 15 项 DEQS 问卷包括一个总体摘要量表和 2 个多项目子量表：日常生活影响和眼部不适症状。心理测量分析表明，DEQS 问卷具有良好的内部一致性、测试-重测可靠性、判别有效性和对变化的反应性。DEQS 问卷与简短形式-8 的心理成分相关良好，与国家眼科研究所视觉功能问卷-25 的 4 个子量表（眼部疼痛、近视力、远视力和心理健康）呈强相关。
DEQS 问卷可有效可靠地评估 DED 对患者日常生活的多方面影响，包括心理健康，并且易于在常规临床实践中使用。
