Centre for Contact Lens Research, University of Waterloo, Waterloo, Ontario, Canada.
Cornea. 2013 Sep;32(9):1204-10. doi: 10.1097/ICO.0b013e318294b0c0.
To characterize the psychometric properties of the standard patient evaluation of eye dryness (SPEED) questionnaire and to validate and compare its performance with 4 existing dry eye questionnaires.
A total of 50 subjects (40 female and 10 male) were enrolled; of these, 30 were symptomatic and 20 asymptomatic, as determined using the ocular surface disease index (OSDI). This study consisted of 2 visits in which all subjects completed 5 different dry eye questionnaires (SPEED, OSDI, dry eye questionnaire, McMonnies dry eye questionnaire, and subjective evaluation of symptom of dryness) in random order at each visit. Clinical measurements were obtained on the first visit. Repeatability was determined using concordance correlation coefficient; dimensionality was determined using principal component, factor, and Rasch analyses; and validity was determined by comparing SPEED scores with dry eye diagnosis based on OSDI (primarily using receiver-operator curve analysis).
The SPEED questionnaire data were found to be unidimensional and repeatable. Three principal components (dryness, burning, and soreness/fatigue) were identified and SPEED between visit concordance correlation coefficient was 0.923 (95% confidence interval, 0.868-0.955). The area under the receiver-operator curves was 0.928. The only clinical measures that correlated "well" with SPEED questionnaire scores were corneal staining (P < 0.05), meibomian gland score (P < 0.05), and meibomian glands yielding liquid secretion score (P < 0.05).
The SPEED questionnaire was shown to be a repeatable and valid instrument for measurement of dry eye symptoms. The SPEED score also correlated significantly with ocular surface staining and clinical measures of meibomian gland function.
描述标准患者眼干评估问卷（SPEED）的心理计量学特性，并验证和比较其与 4 种现有干眼问卷的性能。
共纳入 50 名受试者（40 名女性，10 名男性）；其中 30 名有症状，20 名无症状，通过眼表面疾病指数（OSDI）确定。本研究包括 2 次就诊，每次就诊时所有受试者均以随机顺序完成 5 种不同的干眼问卷（SPEED、OSDI、干眼问卷、McMonnies 干眼问卷和干涩症状主观评估）。第一次就诊时进行临床测量。通过一致性相关系数确定重复性；通过主成分、因子和 Rasch 分析确定维度；并通过比较 SPEED 评分与基于 OSDI 的干眼诊断（主要使用接收者操作特征曲线分析）来确定有效性。
发现 SPEED 问卷数据是单维且可重复的。确定了 3 个主成分（干燥、灼热和疼痛/疲劳），两次就诊的 SPEED 一致性相关系数为 0.923（95%置信区间，0.868-0.955）。接收者操作特征曲线下的面积为 0.928。与 SPEED 问卷评分“相关良好”的唯一临床指标是角膜染色（P < 0.05）、睑板腺评分（P < 0.05）和睑板腺分泌液体评分（P < 0.05）。
SPEED 问卷是一种可重复且有效的干眼症状测量工具。SPEED 评分还与眼表面染色和睑板腺功能的临床测量显著相关。
