巯基化 2-甲基丙烯酰氧乙基磷酸胆碱用于抗污生物传感器平台。
Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform.
机构信息
Institute of Biomaterial and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.
出版信息
Chem Commun (Camb). 2013 Oct 7;49(77):8683-5. doi: 10.1039/c3cc44357d.
PMID:23949309
Abstract
We developed a new building block for a protein- and cell-repellant self-assembled monolayer (SAM) from 2-methacryloyloxyethyl phosphorylcholine (MPC) via a simple Michael-type addition to one mercapto group in alkanedithiol. The thiolated MPC can enable functionalization of a noble metal electrode to minimize noise signal in biosensing.
摘要
我们通过简单的迈克尔加成反应，将 2- 甲基丙烯酰氧基乙基磷酰胆碱（MPC）与烷二硫醇中的一个巯基反应，得到了一种新的蛋白质和细胞排斥自组装单分子层（SAM）的构筑块。巯基化的 MPC 可以实现贵金属电极的功能化，从而最大限度地减少生物传感中的噪声信号。
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