Walker R I
Exp Hematol. 1978 Feb;6(2):172-84.
Sepsis, particularly with endotoxin-containing Gram-negative bacilli, is a serious complication in hosts whose defenses are compromised. This review examines work from our laboratory and others concerning infectious processes which may be critical to the survival of compromised individuals. Several avenues for control of sepsis are proposed. Gram-negative bacteria and their endotoxins can escape from the intestines of compromised animals to contaminate normally sterile host tissues. Endotoxins are especially toxic to compromised hosts because essential components of their inflammatory responses are missing (i.e., leukocytes and platelets in irradiated animals). Therefore, regulation of host responses to endotoxin is no longer possible. It is recommended that sepsis be controlled in compromised individuals through elimination of endogenous microbial agents. Should infection occur in these individuals, they should be transfused with blood cells necessary for clearance of bacteria and endotoxin and restoration of homeostasis.
脓毒症，尤其是由含内毒素的革兰氏阴性杆菌引起的脓毒症，在防御功能受损的宿主中是一种严重的并发症。本综述考察了来自我们实验室及其他机构的有关感染过程的研究工作，这些过程可能对免疫功能受损个体的生存至关重要。文中提出了几种控制脓毒症的途径。革兰氏阴性菌及其内毒素可从免疫功能受损动物的肠道逸出，污染原本无菌的宿主组织。内毒素对免疫功能受损的宿主尤其有毒，因为其炎症反应的关键成分缺失（如受辐照动物体内的白细胞和血小板）。因此，已无法调节宿主对内毒素的反应。建议通过消除内源性微生物来控制免疫功能受损个体的脓毒症。如果这些个体发生感染，应输入清除细菌和内毒素以及恢复体内平衡所需的血细胞。
