肌动蛋白丝的原子模型。

Atomic model of the actin filament.

作者信息

Holmes K C, Popp D, Gebhard W, Kabsch W

机构信息

Max-Planck-Institut für Medizinische Forschung, Abteilung Biophysik, Heidelberg, FRG.

出版信息

Nature. 1990 Sep 6;347(6288):44-9. doi: 10.1038/347044a0.

DOI:10.1038/347044a0

PMID:2395461

Abstract

The F-actin filament has been constructed from the atomic structure of the actin monomer to fit the observed X-ray fibre diagram from oriented gels of F-actin. A unique orientation of the monomer with respect to the actin helix has been found. The main interactions are along the two-start helix with a contribution from a loop extending across the filament axis provided by the molecule in the adjacent strand. There are also contacts along the left-handed genetic helix.

摘要

F-肌动蛋白丝是根据肌动蛋白单体的原子结构构建的，以符合从F-肌动蛋白定向凝胶中观察到的X射线纤维图。已发现单体相对于肌动蛋白螺旋的独特取向。主要相互作用沿着双股螺旋，相邻链中的分子提供的一个环横跨丝轴延伸也有贡献。沿着左手遗传螺旋也存在接触。