使用领结图案的微阵列柱形探测器（mPADs）测量细胞间的拉力。
Measuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors).
作者信息
Cohen Daniel M, Yang Mike T, Chen Christopher S
机构信息
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Methods Mol Biol. 2013;1066:157-68. doi: 10.1007/978-1-62703-604-7_14.
PMID:23955742
Abstract
Cells generate traction forces upon adhesion to the extracellular matrix as well as to neighboring cells. These forces are important for the growth and maintenance of adhesion structures such as focal adhesions and adherens junctions, and may play roles in tissue development. Here, we describe a method for measuring the tugging force transmitted across the cell-cell junction between two paired cells.
摘要
细胞在黏附于细胞外基质以及相邻细胞时会产生牵引力。这些力对于诸如黏着斑和黏附连接等黏附结构的生长和维持很重要，并且可能在组织发育中发挥作用。在这里，我们描述了一种测量在两个配对细胞之间跨细胞 - 细胞连接传递的拉力的方法。
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