Kohshi Kiyotaka, Beppu Takaaki, Tanaka Katsuyuki, Ogawa Kazuhiko, Inoue Osamu, Kukita Ichiro, Clarke Richard E
Division of Hyperbaric Medicine and Emergency Medicine, University Hospital of the Ryukyus, Okinawa, Japan.
Undersea Hyperb Med. 2013 Jul-Aug;40(4):351-62.
Over the past 50 years hyperbaric oxygen (HBO2) therapy has been used in a wide variety of medical conditions, and one of them is cancer. Many clinical studies have been conducted to evaluate potential therapeutic effects of HBO2 as a part of cancer treatment. This review briefly summaries the potential role of HBO2 therapy in the treatment of malignant tumors and radiation injury of the brain. HBO2 therapy is used for the enhancement of radiosensitivity in the treatment of some cancers, including malignant brain tumors. Radiotherapy within 15 minutes following HBO2 exposure, a relatively new treatment regimen, has been studied at several institutes and has demonstrated promising clinical results for malignant gliomas of the brain. HBO2 therapy also increases sensitivity to some antineoplastic agents; non-randomized clinical trials using carboplatin-based chemotherapy combined with HBO2 show a significant advantage in survival for recurrent malignant gliomas. The possibilities of combining HBO2 therapy with radiotherapy and/or chemotherapy to overcome newly diagnosed and recurrent malignant gliomas deserve extensive clinical trials. HBO2 therapy also shows promising potential for the treatment and/or prevention of radiation injury of the brain after stereotactic radiosurgery for brain lesions. The possibilities with HBO2 to enhance the therapeutic effect of irradiation per se, and to even increase the radiation dose if there are ways to combat the side effects, should boost new scientific interest into the whole field of oncology looking for new armamentaria to fight cancer.
在过去50年里，高压氧（HBO2）疗法已被用于多种医疗状况，其中之一就是癌症。已经开展了许多临床研究来评估HBO2作为癌症治疗一部分的潜在治疗效果。这篇综述简要总结了HBO2疗法在恶性肿瘤治疗和脑辐射损伤治疗中的潜在作用。HBO2疗法用于增强某些癌症（包括恶性脑肿瘤）治疗中的放射敏感性。在HBO2暴露后15分钟内进行放疗，这是一种相对较新的治疗方案，已在多家机构进行研究，并已证明对脑恶性胶质瘤有良好的临床效果。HBO2疗法还能增加对某些抗肿瘤药物的敏感性；使用以卡铂为基础的化疗联合HBO2的非随机临床试验显示，复发性恶性胶质瘤患者的生存率有显著优势。将HBO2疗法与放疗和/或化疗联合以攻克新诊断和复发性恶性胶质瘤的可能性值得进行广泛的临床试验。HBO2疗法在治疗和/或预防脑病变立体定向放射外科术后的脑辐射损伤方面也显示出有前景的潜力。如果有办法对抗副作用，HBO2增强放疗本身治疗效果甚至增加辐射剂量的可能性，应该会激发肿瘤学整个领域对寻找对抗癌症新武器的新科学兴趣。
