人参皂苷 Rh2 可改善小鼠的学习和记忆能力。
Ginsenoside Rh2 improves learning and memory in mice.
机构信息
Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejon, Korea.
出版信息
J Med Food. 2013 Aug;16(8):772-6. doi: 10.1089/jmf.2012.2564.
Abstract
A wide range of plant foods and dietary supplements are able to modify the functioning of the central nervous system. In the present study, we observed that oral administration of ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning and memory. Spatial memory and learning was evaluated in mice by hippocampus-dependent tasks (Morris water maze test) and immunohistochemical marker of cell genesis bromodeoxyuridine. Ginsenoside Rh2 treatment (30 days) promoted cell survival and genesis. Further, ginsenoside Rh2 treatment in enriched condition had no significant effects on cell survival compared with standard condition exposure. These results revealed that ginsenoside Rh2-mediated spatial learning and memory improvement was associated with cell genesis and survival and may be parallel to the mechanism of environmental enrichment. Therefore, ginsenoside Rh2 may have efficacy as a dietary supplement for spatial learning and memory improvement.
摘要
大量植物性食物和膳食补充剂能够调节中枢神经系统的功能。在本研究中，我们观察到口服人参皂苷 Rh2（10mg/mL）3 周可显著改善空间学习和记忆能力。通过海马依赖性任务（Morris 水迷宫测试）和细胞发生标志物溴脱氧尿苷的免疫组织化学检测评估小鼠的空间记忆和学习能力。人参皂苷 Rh2 处理（30 天）促进了细胞存活和发生。此外，与标准条件暴露相比，丰富环境中的人参皂苷 Rh2 处理对细胞存活没有显著影响。这些结果表明，人参皂苷 Rh2 介导的空间学习和记忆改善与细胞发生和存活有关，可能与人参皂苷 Rh2 与环境富集的机制平行。因此，人参皂苷 Rh2 可能作为一种膳食补充剂用于改善空间学习和记忆。
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