Kwon Kee Hwan, Lee Young Chan, Chung Joo-Ho, Eun Young Gyu
1 Department of Otorhinolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, School of Medicine, Hallym University, Seoul, Republic of Korea.
J Invest Surg. 2013 Dec;26(6):319-24. doi: 10.3109/08941939.2013.805857. Epub 2013 Aug 19.
The association between polymorphism of CC chemokine ligand 5 (CCL5) and cancer has been reported in several studies, however, there is no data in papillary thyroid cancer (PTC).
The aim of this study was to investigate whether a promoter single nucleotide polymorphisms (SNP) in CCL5 contributes to the development of PTC and assess the relationships between the CCL5 SNP and the cliniopathologic characteristics of PTC.
One promoter SNP (rs2107538, -281C/T) in CCL5 was genotyped using direct sequencing in 93 PTC patients and 212 healthy controls. Genetic data were analyzed using SNPStats, Helixtree, and SNPAnalyzer. PTC patients were dichotomized and compared with respect to cliniopathologic characteristics of PTC.
An association was evident between PTC and SNP (rs2107538) in CCL5 [codominant model 2 (T/T vs. C/C), OR = 2.74, 95% CI = 1.18-6.37, p = .019; dominant model, OR = 2.25, 95% CI = 1.01-5.03, p = .049; recessive model, OR = 1.73, 95% CI = 1.06-2.82, p = .030]. When the genetic relationships between SNP and subgroups of PTC patients were assessed, SNP rs2107538 in CCL5 was not associated with any clinicopathologic characteristics of PTC.
SNP in the CCL5 -281 promoter gene could increase the risk of developing PTC in Koreans.
多项研究报道了CC趋化因子配体5（CCL5）多态性与癌症之间的关联，然而，甲状腺乳头状癌（PTC）方面尚无相关数据。
本研究旨在调查CCL5启动子单核苷酸多态性（SNP）是否与PTC的发生有关，并评估CCL5 SNP与PTC临床病理特征之间的关系。
采用直接测序法对93例PTC患者和212例健康对照者进行CCL5一个启动子SNP（rs2107538，-281C/T）基因分型。使用SNPStats、Helixtree和SNPAnalyzer分析遗传数据。将PTC患者进行二分法分类，并就PTC的临床病理特征进行比较。
PTC与CCL5中的SNP（rs2107538）之间存在明显关联[共显性模型2（T/T与C/C），OR = 2.74，95%CI = 1.18 - 6.37，p = 0.019；显性模型，OR = 2.25，95%CI = 1.01 - 5.03，p = 0.049；隐性模型，OR = 1.73，95%CI = 1.06 - 2.82，p = 0.030]。在评估SNP与PTC患者亚组之间的遗传关系时，CCL5中的SNP rs2107538与PTC的任何临床病理特征均无关联。
CCL5 -281启动子基因中的SNP可能会增加韩国人患PTC的风险。
