Department of the Woman, the Child and General and Specialized Surgery, Second University of Naples, Naples, Italy.
Eur J Obstet Gynecol Reprod Biol. 2013 Oct;170(2):391-5. doi: 10.1016/j.ejogrb.2013.07.038. Epub 2013 Aug 16.
To identify possible sonographic prenatal parameters and postnatal parameters in order to obtain more bankable cord blood units (CBUs) containing a high number of primitive progenitor cells, allowing CBUs to be used as a source of haematopoietic progenitors for clinical transplantation.
Prospective study undertaken in the Department of Gynaecology, Obstetrics and Reproductive Science, Second University of Naples, Italy. In total, 219 unrelated CBU donors were enrolled. Ultrasound parameters (biparietal diameter, head circumference, abdominal circumference, femur length, estimation of fetal weight, umbilical artery pulsatility index), collected at hospital admission, together with birth weight and placental weight, were correlated with bankable CBU parameters (CBU volume, total nucleated cell count, CD34+ cell count).
Femur length and abdominal circumference correlated positively with bankable CBUs. Receiver operating curve analysis showed that these parameters can identify bankable CBUs.
This is the first prospective study to show the relationship between ultrasonographic fetal parameters at term and the possibility of obtaining high-quality CBUs. As such, cord blood banking could be improved worldwide by performing low-cost ultrasonographic scans.
确定可能的产前和产后超声参数，以获得更多含有大量原始祖细胞的可储存脐带血单位（CBU），从而使 CBUs 能够作为临床移植造血祖细胞的来源。
在意大利那不勒斯第二大学妇产科和生殖科学系进行的前瞻性研究。共纳入 219 名无关的 CBU 供体。在入院时采集超声参数（双顶径、头围、腹围、股骨长、胎儿体重估计、脐动脉搏动指数），并与出生体重和胎盘重量相关联，这些参数与可储存 CBU 参数（CBU 体积、总核细胞计数、CD34+细胞计数）相关。
股骨长和腹围与可储存 CBUs 呈正相关。受试者工作特征曲线分析表明，这些参数可识别可储存 CBUs。
这是第一项前瞻性研究，表明足月胎儿超声参数与获得高质量 CBUs 的可能性之间存在关系。因此，通过进行低成本的超声扫描，可在全球范围内改善脐带血储存。
