• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

甲状腺素运载蛋白基因表达的相似性以及转录因子的差异：肝脏和卵黄囊与脉络丛的比较。

Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus.

作者信息

Costa R H, Van Dyke T A, Yan C, Kuo F, Darnell J E

机构信息

Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612.

出版信息

Proc Natl Acad Sci U S A. 1990 Sep;87(17):6589-93. doi: 10.1073/pnas.87.17.6589.

DOI:10.1073/pnas.87.17.6589
PMID:2395861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC54582/
Abstract

The serum thyroxine-binding protein, transthyretin (TTR), is made by hepatocytes and by choroid plexus epithelium in adults and by yolk sac cells in embryogenesis. Four hepatocyte nuclear factors (HNF-1, -3, and -4 and C/EBP) that are present in liver but not in most other adult tissues bind DNA sites in the TTR gene that are sufficient to direct transgenic expression. Three of these proteins were also found in yolk sac cells, which also express the transgene. A limited transgenic construct is not active in the choroid plexus and a TTR-producing choroid plexus tumor lacks three of the liver-enriched DNA-binding proteins. We conclude that cell-specific expression of TTR is regulated at least in part by the differential cellular distribution of positive-acting transcription factors.

摘要

血清甲状腺素结合蛋白，即转甲状腺素蛋白（TTR），在成体中由肝细胞和脉络丛上皮细胞产生，在胚胎发育过程中由卵黄囊细胞产生。四种存在于肝脏而非大多数其他成体组织中的肝细胞核因子（HNF-1、-3、-4和C/EBP）结合TTR基因中的DNA位点，这些位点足以指导转基因表达。其中三种蛋白质也存在于卵黄囊细胞中，卵黄囊细胞也表达该转基因。一个有限的转基因构建体在脉络丛中无活性，并且产生TTR的脉络丛肿瘤缺乏三种肝脏富集的DNA结合蛋白。我们得出结论，TTR的细胞特异性表达至少部分受正性作用转录因子的差异细胞分布调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/ff35227114bf/pnas01042-0125-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/80c147ccdae8/pnas01042-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/a224afda319f/pnas01042-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/6ffb0f707cda/pnas01042-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/ff4b9306debd/pnas01042-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/ff35227114bf/pnas01042-0125-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/80c147ccdae8/pnas01042-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/a224afda319f/pnas01042-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/6ffb0f707cda/pnas01042-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/ff4b9306debd/pnas01042-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b151/54582/ff35227114bf/pnas01042-0125-b.jpg

相似文献

1
Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus.甲状腺素运载蛋白基因表达的相似性以及转录因子的差异：肝脏和卵黄囊与脉络丛的比较。
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6589-93. doi: 10.1073/pnas.87.17.6589.
2
Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice.不同的正负调控元件控制转甲状腺素蛋白在转基因小鼠肝脏和脉络丛中的有限表达。
EMBO J. 1990 Mar;9(3):869-78. doi: 10.1002/j.1460-2075.1990.tb08184.x.
3
Identification of a transthyretin enhancer site that selectively binds the hepatocyte nuclear factor-3 beta isoform.一种选择性结合肝细胞核因子-3β异构体的转甲状腺素蛋白增强子位点的鉴定。
Gene Expr. 1996;6(1):23-33.
4
Prealbumin gene expression during mouse development studied by in situ hybridization.
Cell Differ. 1987 Nov;22(1):1-9. doi: 10.1016/0045-6039(87)90408-8.
5
Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region.对小鼠甲状腺素运载蛋白（TTR）启动子中肝细胞核因子（HNF）结合位点进行定点诱变，揭示了其与增强子区域的协同相互作用。
Nucleic Acids Res. 1991 Aug 11;19(15):4139-45. doi: 10.1093/nar/19.15.4139.
6
Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC.利用人转甲状腺素蛋白 BAC，准确、强、稳定报告转基因小鼠脉络丛上皮细胞。
Fluids Barriers CNS. 2018 Aug 16;15(1):22. doi: 10.1186/s12987-018-0107-4.
7
A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse.
J Biochem. 1995 Jan;117(1):169-75. doi: 10.1093/oxfordjournals.jbchem.a124705.
8
Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells.肝富集转录因子的差异调节解释了肝癌细胞中白蛋白和转甲状腺素蛋白基因表达的变化。
New Biol. 1991 Mar;3(3):289-96.
9
High levels of messenger RNA for transthyretin (prealbumin) in human choroid plexus.人脉络丛中转甲状腺素蛋白（前白蛋白）的信使核糖核酸水平较高。
Neurosci Lett. 1986 May 23;66(3):311-5. doi: 10.1016/0304-3940(86)90037-6.
10
Ontogenesis of transthyretin gene expression in chicken choroid plexus and liver.
Comp Biochem Physiol B. 1991;100(2):329-38. doi: 10.1016/0305-0491(91)90383-o.

引用本文的文献

1
The aging choroid plexus and its relationship with gut dysbiosis and Klotho decline: possible intervention strategies.衰老的脉络丛及其与肠道微生物群失调和klotho蛋白下降的关系：可能的干预策略。
Geroscience. 2025 Jul 22. doi: 10.1007/s11357-025-01797-1.
2
The Journey of Human Transthyretin: Synthesis, Structure Stability, and Catabolism.人转甲状腺素蛋白的历程：合成、结构稳定性及分解代谢
Biomedicines. 2022 Aug 6;10(8):1906. doi: 10.3390/biomedicines10081906.
3
Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease.

本文引用的文献

1
Transcriptional control in the production of liver-specific mRNAs.肝脏特异性mRNA产生过程中的转录调控。
Cell. 1981 Mar;23(3):731-9. doi: 10.1016/0092-8674(81)90436-0.
2
Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver.成年和胚胎肝脏中特定信使核糖核酸的转录和转录后调控
J Mol Biol. 1984 Oct 15;179(1):21-35. doi: 10.1016/0022-2836(84)90304-8.
3
Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.小鼠内脏卵黄囊和胎儿肝脏中血清蛋白基因表达模式。
核受体与非酒精性脂肪性肝病的转录调控。
Mol Metab. 2021 Aug;50:101119. doi: 10.1016/j.molmet.2020.101119. Epub 2020 Nov 18.
4
Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC.利用人转甲状腺素蛋白 BAC，准确、强、稳定报告转基因小鼠脉络丛上皮细胞。
Fluids Barriers CNS. 2018 Aug 16;15(1):22. doi: 10.1186/s12987-018-0107-4.
5
Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose.鉴定 HNF-4α 为关键转录因子，促进 ChREBP 表达以响应葡萄糖。
Sci Rep. 2016 Mar 31;6:23944. doi: 10.1038/srep23944.
6
Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt).野生型转甲状腺素蛋白淀粉样变性（ATTRwt）中转甲状腺素蛋白基因的遗传变异。
Hum Genet. 2015 Jan;134(1):111-21. doi: 10.1007/s00439-014-1499-0. Epub 2014 Nov 4.
7
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.系统性淀粉样前体转甲状腺素蛋白 (TTR) 在 SH-SY5Y 人神经母细胞瘤细胞和 APP23 阿尔茨海默病模型小鼠中作为一种受 HSF1 调节的神经元应激蛋白。
J Neurosci. 2014 May 21;34(21):7253-65. doi: 10.1523/JNEUROSCI.4936-13.2014.
8
Gene expression profiles in CHA3 and CHA4 human embryonic stem cells and embryoid bodies.CHA3 和 CHA4 人胚胎干细胞和类胚体中的基因表达谱。
Mol Cells. 2011 Apr;31(4):315-26. doi: 10.1007/s10059-011-0039-1. Epub 2011 Feb 22.
9
Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.前内脏内胚层 SMAD4 信号转导特异性地规定了小鼠胚胎的前体模式和头部诱导。
Int J Biol Sci. 2010 Sep 27;6(6):569-83. doi: 10.7150/ijbs.6.569.
10
A comparative analysis of extra-embryonic endoderm cell lines.胚胎外内胚层细胞系的比较分析。
PLoS One. 2010 Aug 6;5(8):e12016. doi: 10.1371/journal.pone.0012016.
EMBO J. 1984 Aug;3(8):1881-5. doi: 10.1002/j.1460-2075.1984.tb02062.x.
4
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.通过聚丙烯酰胺凝胶电泳研究乳糖阻遏物-操纵基因相互作用的平衡与动力学
Nucleic Acids Res. 1981 Dec 11;9(23):6505-25. doi: 10.1093/nar/9.23.6505.
5
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system.一种用于定量蛋白质与特定DNA区域结合的凝胶电泳方法：应用于大肠杆菌乳糖操纵子调控系统的组分
Nucleic Acids Res. 1981 Jul 10;9(13):3047-60. doi: 10.1093/nar/9.13.3047.
6
Factors involved in control of tissue-specific expression of albumin gene.参与白蛋白基因组织特异性表达调控的因素。
Cell. 1987 Aug 14;50(4):627-38. doi: 10.1016/0092-8674(87)90036-5.
7
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters.一种肝脏特异性核因子与纤维蛋白原和α1-抗胰蛋白酶启动子的相互作用。
Science. 1987 Oct 30;238(4827):688-92. doi: 10.1126/science.3499668.
8
Retinol-binding protein and transthyretin mRNA levels in visceral yolk sac and liver during fetal development in the rat.大鼠胎儿发育过程中内脏卵黄囊和肝脏中视黄醇结合蛋白及甲状腺素运载蛋白的mRNA水平
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7330-4. doi: 10.1073/pnas.83.19.7330.
9
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.亮氨酸拉链：一类新型DNA结合蛋白共有的一种假设结构。
Science. 1988 Jun 24;240(4860):1759-64. doi: 10.1126/science.3289117.
10
Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter.
EMBO J. 1988 Jul;7(7):2075-87. doi: 10.1002/j.1460-2075.1988.tb03047.x.