Weger Martin, Pichler Tamara, Franke Gabriele H, Haas Anton, Thaler Herbert V, Kraigher-Krainer Nora, Groselj-Strele Andrea, Wedrich Andreas, Rabensteiner Dieter F
*Department of Ophthalmology, Medical University of Graz, Graz, Austria; †Department of Rehabilitation Psychology, Applied Human Sciences, University of Applied Sciences Magdeburg-Stendal, Stendal, Germany; and ‡Center for Medical Research, Office of Biostatistics, Medical University of Graz, Graz, Austria.
Retina. 2014 Mar;34(3):539-45. doi: 10.1097/IAE.0b013e3182a0e42e.
Central retinal artery occlusion (CRAO) is a major cause for severe visual impairment. Its effect on vision-related quality of life has not yet been determined. The purpose of the present study was thus to assess vision-related quality of life in patients with CRAO using the 39-item National Eye Institute Visual Function Questionnaire.
The case-control study comprised 26 patients with unilateral CRAO and a control group consisting of 26 control subjects, matched for age and sex. Vision-related quality of life was measured using the 39-item National Eye Institute Visual Function Questionnaire.
After Bonferroni correction, the median 39-item National Eye Institute Visual Function Questionnaire composite score was significantly lower in patients with CRAO than in those in the control group (P(corr) < 0.001). Patients with CRAO showed significantly lower median scores in 9 of 12 subscales: general vision (P(corr) < 0.001), peripheral vision (P(corr) < 0.001), difficulties with near-vision activities (P(corr) < 0.001), difficulties with distance-vision activities (P(corr) < 0.001), role difficulties as a result of vision problems (P(corr) < 0.001), dependency on others because of vision problems (P(corr) < 0.001), limitations in social functioning because of vision problems (P(corr) < 0.001), mental health symptoms because of vision problems (P(corr) < 0.001), and general health (P(corr) = 0.008).
Our data suggest that vision-related quality of life is reduced in patients with CRAO.
视网膜中央动脉阻塞（CRAO）是严重视力损害的主要原因。其对与视力相关的生活质量的影响尚未确定。因此，本研究的目的是使用39项美国国立眼科研究所视觉功能问卷评估CRAO患者与视力相关的生活质量。
病例对照研究包括26名单侧CRAO患者和一个由26名对照受试者组成的对照组，两组在年龄和性别上相匹配。使用39项美国国立眼科研究所视觉功能问卷测量与视力相关的生活质量。
经过Bonferroni校正后，CRAO患者的39项美国国立眼科研究所视觉功能问卷综合得分中位数显著低于对照组（P（校正）<0.001）。CRAO患者在12个分量表中的9个分量表得分中位数显著较低：总体视力（P（校正）<0.001）、周边视力（P（校正）<0.001）、近视力活动困难（P（校正）<0.001）、远视力活动困难（P（校正）<0.001）、因视力问题导致的角色困难（P（校正）<0.001）、因视力问题对他人的依赖（P（校正）<0.001）、因视力问题导致的社交功能受限（P（校正）<0.001）、因视力问题出现的心理健康症状（P（校正）<0.001）以及总体健康状况（P（校正）=0.008）。
我们的数据表明，CRAO患者与视力相关的生活质量降低。
