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Immunology: Cytosolic DNA sensing unraveled.

作者信息

Panne Daniel

机构信息

European Molecular Biology Laboratory Grenoble, Grenoble, France.

出版信息

Nat Chem Biol. 2013 Sep;9(9):533-4. doi: 10.1038/nchembio.1318.

DOI:10.1038/nchembio.1318

PMID:23959130

Abstract

摘要

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Science. 2013 Feb 15;339(6121):763-4. doi: 10.1126/science.1234724.

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Methods Enzymol. 2019;629:17-33. doi: 10.1016/bs.mie.2019.07.042. Epub 2019 Aug 9.

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EMBO Rep. 2017 Oct;18(10):1707-1715. doi: 10.15252/embr.201744017. Epub 2017 Aug 10.

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Structural mechanism of cytosolic DNA sensing by cGAS.

Nature. 2013 Jun 20;498(7454):332-7. doi: 10.1038/nature12305. Epub 2013 May 30.

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

Nature. 2013 Jun 20;498(7454):380-4. doi: 10.1038/nature12306. Epub 2013 May 30.

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

Cell Rep. 2013 May 30;3(5):1355-61. doi: 10.1016/j.celrep.2013.05.009. Epub 2013 May 23.

Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.

Cell Rep. 2013 May 30;3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013 May 23.

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Cell. 2013 May 23;153(5):1094-107. doi: 10.1016/j.cell.2013.04.046. Epub 2013 May 3.

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Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20.

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Science. 2013 Feb 15;339(6121):826-30. doi: 10.1126/science.1229963. Epub 2012 Dec 20.

STING is a direct innate immune sensor of cyclic di-GMP.

Nature. 2011 Sep 25;478(7370):515-8. doi: 10.1038/nature10429.

Cytosolic DNA sensors regulating type I interferon induction.

Trends Immunol. 2011 Dec;32(12):574-81. doi: 10.1016/j.it.2011.08.004. Epub 2011 Sep 21.