四链体结构对 G-四链体结合阳离子卟啉 TMPyP4·Cu 进行 DNA 不对称催化的影响。
The influence of G-quadruplex structure on DNA-based asymmetric catalysis using the G-quadruplex-bound cationic porphyrin TMPyP4·Cu.
机构信息
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstr. 40, D-48149 Münster, Germany.
出版信息
Org Biomol Chem. 2013 Sep 25;11(40):6940-5. doi: 10.1039/c3ob41366g.
PMID:23959382
Abstract
The DNA G-quadruplex-binding porphyrin TMPyP4·Cu was found to form efficient hybrid catalysts for DNA-based asymmetric catalysis when bound to DNA G-quadruplexes. Nucleobase substitution experiments using human telomere-derived G-quadruplex sequences suggest binding of the porphyrin on the 3'-face.
摘要
当与 DNA G-四链体结合时，DNA G-四链体结合卟啉 TMPyP4·Cu 被发现可形成用于基于 DNA 的不对称催化的有效杂化催化剂。用人端粒衍生的 G-四链体序列进行的核碱基取代实验表明卟啉在 3'-面上的结合。
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