Mavrogeni Sophie, Bratis Konstantinos, van Wijk Kees, Kyrou Louisa, Kattamis Antonios, Reiber Johan H C
Onassis Cardiac Surgery Center, Athens, Greece.
Medis Medical Imaging Systems BV, P.O. Box 384, 2300 AJ, Leiden, The Netherlands.
Int J Cardiovasc Imaging. 2013 Oct;29(7):1511-1516. doi: 10.1007/s10554-013-0242-6. Epub 2013 Aug 20.
In b-thalassemia major (TM) multiple blood transfusions are needed for survival. As a consequence these patients present iron overload in different organs, including heart and liver. Magnetic resonance imaging using a bright blood gradient echo sequence has been successfully used for the quantification of tissue iron. The aim is to evaluate of the accuracy and precision in the evaluation of liver and myocardial T2* values in TM using two different analytical software solutions. Thirty TM patients aged 20-56 years (mean age 37, 11M/19F) were scanned in a GE 1.5 T CVI system. Each scan included the measurement of heart and liver T2* and the left ventricular ejection fraction using standard techniques. The analysis of T2* of heart and liver was done using the two different analytical software solutions: the "Functool" protocol by GE and the T2* module of QMassMR v7.4 by Medis medical imaging systems bv, Leiden, The Netherlands. The cardiac and liver T2* measurements showed that both software solutions allow reproducible measurements with low intra-observer variations (accuracy < 0.3 ms, precision < 2 ms). There is a small but significant difference between the two solutions of 2.4 ms in cardiac and of 1.5 ms in liver measurements. However, from the clinical point of view these differences (<2 ms) are small with negligible impact on the patient's treatment management. The comparison of the T2* measurements using the two analytical software solutions proved that both techniques enable reproducible measurements for the evaluation of iron overload in heart and liver.
在重型β地中海贫血（TM）中，患者需要多次输血才能存活。因此，这些患者的不同器官（包括心脏和肝脏）会出现铁过载。使用亮血梯度回波序列的磁共振成像已成功用于组织铁含量的定量分析。目的是使用两种不同的分析软件解决方案，评估TM患者肝脏和心肌T2值评估的准确性和精密度。30例年龄在20 - 56岁（平均年龄37岁，11例男性/19例女性）的TM患者在GE 1.5T CVI系统中进行扫描。每次扫描都包括使用标准技术测量心脏和肝脏的T2以及左心室射血分数。使用两种不同的分析软件解决方案对心脏和肝脏的T2进行分析：GE公司的“Functool”协议以及荷兰莱顿Medis医学成像系统公司的QMassMR v7.4的T2模块。心脏和肝脏T2测量结果表明，两种软件解决方案均能实现可重复测量，观察者内差异较小（准确性<0.3毫秒，精密度<2毫秒）。两种解决方案之间存在细微但显著的差异，心脏测量差异为2.4毫秒，肝脏测量差异为1.5毫秒。然而，从临床角度来看，这些差异（<2毫秒）很小，对患者治疗管理的影响可忽略不计。使用两种分析软件解决方案对T2测量结果进行比较证明，两种技术均可实现可重复测量，用于评估心脏和肝脏的铁过载情况。
