Department of General Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 20080, China.
Med Oncol. 2013 Dec;30(4):688. doi: 10.1007/s12032-013-0688-3. Epub 2013 Aug 20.
T-box2 (TBX2) plays a critical role in embryonic development. Recently, deregulated expression of TBX2 has been implicated in several malignancies. However, the expression and the role of TBX2 in colorectal cancer (CRC) remain unclear. In this study, we found that TBX2 was obviously up-regulated in CRC in comparison with the corresponding normal mucosa at transcriptional and protein level. Up-expression of TBX2 was significantly associated with depth of tumor invasion (P = 0.006), distant metastasis (P = 0.038), advanced AJCC stage (P = 0.008), and relapse (P = 0.003). TBX2 was a significantly prognostic factor for decreased survival and increased disease recurrence independent of tumor stage(II, III stage) and functioned as a biomarker to identify prognosis of patients with CRC (OS: HR 2.154; 95% CI 1.019-4.551; P = 0.044, DFS: HR 2.253; 95% CI 1.109-4.575; P = 0.025). Furthermore, TBX2 could serve as a potential target of cancer drug therapy.
T 盒转录因子 2（TBX2）在胚胎发育中起着关键作用。最近，TBX2 的表达失调与几种恶性肿瘤有关。然而，TBX2 在结直肠癌（CRC）中的表达和作用仍不清楚。在这项研究中，我们发现与相应的正常黏膜相比，TBX2 在 CRC 中在转录和蛋白水平上明显上调。TBX2 的高表达与肿瘤浸润深度（P = 0.006）、远处转移（P = 0.038）、晚期 AJCC 分期（P = 0.008）和复发（P = 0.003）显著相关。TBX2 是一个独立于肿瘤分期（II、III 期）和功能的预后因素，是 CRC 患者生存和疾病复发的显著预后因素（OS：HR 2.154；95%CI 1.019-4.551；P = 0.044，DFS：HR 2.253；95%CI 1.109-4.575；P = 0.025）。此外，TBX2 可以作为癌症药物治疗的潜在靶点。
