Dong Xifeng, Qiu Xiao-chun, Liu Qian, Jia Jack
Tumour Biol. 2013 Dec;34(6):3273-8. doi: 10.1007/s13277-013-1032-4.
Innovation in the last decade has endowed nanotechnology with an assortment of tools for drug delivery system, imaging, and sensing in cancer research. These rapidly emerging tools are indicative of a burgeoning field ready to expand into medical applications. The aim of this study is to analyze the applications of nanotechnology in oncology with bibliometric methods and evaluate development in this field. Literature search was performed using PubMed search engines with MeSH terms (all)--nanotechnology, nanomedicine, nanoparticle, nanocapsules, micellar systems, and oncology or cancer or neoplasms. Within 2,543 articles from 2002 to 2011 in over 50 medical magazines from over 30 countries, we did a series analysis on these articles' countries, keywords, and authors. Our results show that articles in nanotechnology in oncology are increasing year by year, especially in recent years. Quantity and quality of the articles are becoming more and influential. In the global research, the USA is leading in this field, accounting for half above of the whole articles, followed by countries like Japan, Germany, and France and also some emerging nations like China, in the second place, and India. Subjects like nanoparticles, tumor marker, and drug delivery are the common research focus. So, with more and more scientists' interests and attention drawn to this field, it is likely to make major breakthroughs in the coming years.
过去十年的创新为纳米技术配备了一系列用于癌症研究中药物递送系统、成像和传感的工具。这些迅速涌现的工具表明一个新兴领域正准备扩展到医学应用中。本研究的目的是用文献计量学方法分析纳米技术在肿瘤学中的应用,并评估该领域的发展。使用PubMed搜索引擎,以医学主题词(全部)——纳米技术、纳米医学、纳米颗粒、纳米胶囊、胶束系统以及肿瘤学或癌症或肿瘤进行文献检索。在来自30多个国家的50多种医学杂志上发表的2002年至2011年的2543篇文章中,我们对这些文章的国家、关键词和作者进行了系列分析。我们的结果表明,肿瘤学中纳米技术方面的文章逐年增加,尤其是近年来。文章的数量和质量正变得越来越多且有影响力。在全球研究中,美国在该领域处于领先地位,占全部文章的一半以上,其次是日本、德国、法国等国家,还有一些新兴国家如中国位居第二,以及印度。纳米颗粒、肿瘤标志物和药物递送等主题是常见的研究重点。所以,随着越来越多科学家对该领域的兴趣和关注,未来几年很可能会取得重大突破。