Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar, India.
Nanomedicine. 2012 Feb;8(2):147-66. doi: 10.1016/j.nano.2011.05.016. Epub 2011 Jun 7.
Drug delivery is an interdisciplinary and independent field of research and is gaining the attention of pharmaceutical researchers, medical doctors and industry. A safe and targeted drug delivery could improve the performance of some classic medicines already on the market, and moreover, will have implications for the development and success of new therapeutic strategies such as anticancer drug delivery, peptide and protein delivery and gene therapy. In the last decade, several drug-delivery technologies have emerged and a fascinating part of this field is the development of nanoscale drug delivery devices. Nanoparticles (NPs) have been developed as an important strategy to deliver conventional drugs, recombinant proteins, vaccines and more recently, nucleotides. NPs and other colloidal drug-delivery systems modify the kinetics, body distribution and drug release of an associated drug. This review article focuses on the potential of nanotechnology in medicine and discusses different nanoparticulate drug-delivery systems including polymeric NPs, ceramic NPs, magnetic NPs, polymeric micelles and dendrimers as well as their applications in therapeutics, diagnostics and imaging.
This comprehensive review focuses on different nanoparticulate drug-delivery systems including polymeric NPs, ceramic NPs, magnetic NPs, polymeric micelles and dendrimers as well as their applications in therapeutics, diagnostics and imaging.
药物输送是一个跨学科和独立的研究领域，正在引起制药研究人员、医生和行业的关注。安全和靶向药物输送可以提高一些已在市场上的经典药物的疗效，此外，对于新的治疗策略的开发和成功也具有重要意义，如抗癌药物输送、肽和蛋白质输送和基因治疗。在过去的十年中，出现了几种药物输送技术，而该领域引人入胜的一部分是纳米级药物输送装置的发展。纳米颗粒 (NPs) 的开发是一种将常规药物、重组蛋白、疫苗和最近的核苷酸递送至体内的重要策略。NPs 和其他胶体药物输送系统改变了相关药物的动力学、体内分布和药物释放。本文综述了纳米技术在医学中的应用，并讨论了不同的纳米颗粒药物输送系统，包括聚合物 NPs、陶瓷 NPs、磁性 NPs、聚合物胶束和树枝状大分子，以及它们在治疗、诊断和成像中的应用。
这篇全面的综述重点介绍了不同的纳米颗粒药物输送系统，包括聚合物 NPs、陶瓷 NPs、磁性 NPs、聚合物胶束和树枝状大分子，以及它们在治疗、诊断和成像中的应用。
