School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran.
Department of Electrical Engineering, Politecnico di Milano, Milan, Italy.
Int J Nanomedicine. 2020 Jun 26;15:4453-4470. doi: 10.2147/IJN.S247210. eCollection 2020.
Exosomes are small vesicles produced by almost all cells in the body and found in all biofluids. Cancer cell-derived exosomes are known to have distinct, measurable signatures, applicable for early cancer diagnosis. Despite the present bibliometric studies on "Cancer detection" and "Nanoparticles", no single study exists to deal with "Exosome" bibliometric study.
This bibliometric work investigated the publication trends of "Exosomes" nanoparticles and its application in cancer detection, for the literature from 2008 to July 2019. The data were collected from the Web of Science Core Collection. There were variant visual maps generated to show annual publication, most- relevant authors, sources, countries, topics and keywords. The network analysis of these studies was investigated to evaluate the research trends in the field of exosomes. In addition, the data were qualitatively analyzed according to 22 top-cited articles, illustrating the frequently used subjects and methods in exosomes research area.
The results showed that the documents in this field have improved the citation rate. The top-relevant papers are mostly published in Scientific Reports journal which has lost its popularity after 2017, while today, Analytical Chemistry is leading in publishing the most articles related to exosomes. The documents containing keywords of plasma, cells, cancer, biomarkers, and vesicles as keywords plus, are more likely to be published in PLoS One journal. The clustering of the keywords network showed that the keyword theme of "extracellular vesicles" has the highest centrality rate. In global research, USA is the most corresponding country, followed by China, Korea and Australia. Based on the qualitative analysis, the published documents with at least 50 citations have used exosome release, cargo, detection, purification and secretion, as their targets and applied cell culture or isolation as their methods.
The bibliometric study on exosomes nanoparticles for cancer detection provides a clear vision of the future research direction and identifies the potential opportunities and challenges. This may lead new researchers to select the proper subfields in exosome-related research fields.
外泌体是几乎所有细胞在体内产生的小囊泡，存在于所有生物体液中。已知癌细胞来源的外泌体具有独特的、可测量的特征，可用于早期癌症诊断。尽管目前有关于“癌症检测”和“纳米粒子”的文献计量学研究，但没有单独的研究来处理“外泌体”文献计量学研究。
本文献计量学研究调查了 2008 年至 2019 年 7 月期间外泌体纳米粒子及其在癌症检测中的应用的出版物趋势。数据来自 Web of Science 核心合集。生成了各种可视化地图，以显示年度出版物、最相关的作者、来源、国家、主题和关键词。对这些研究进行了网络分析，以评估外泌体领域的研究趋势。此外，根据 22 篇高引用文章对数据进行了定性分析，说明了外泌体研究领域常用的主题和方法。
该领域的文献表明，其引文率有所提高。排名靠前的相关论文主要发表在《Scientific Reports》杂志上，但该杂志在 2017 年后已不再受欢迎，而如今，《Analytical Chemistry》在发表与外泌体相关的文章方面处于领先地位。包含血浆、细胞、癌症、生物标志物和囊泡等关键词加的文献更有可能发表在《PLoS One》杂志上。关键词网络的聚类显示，“细胞外囊泡”这一关键词主题具有最高的中心度。在全球研究中，美国是最对应的国家，其次是中国、韩国和澳大利亚。基于定性分析，至少有 50 篇引用的文献已将外泌体的释放、货物、检测、纯化和分泌作为目标，并应用细胞培养或分离作为方法。
外泌体纳米粒子用于癌症检测的文献计量学研究提供了未来研究方向的清晰愿景，并确定了潜在的机遇和挑战。这可能会引导新的研究人员选择外泌体相关研究领域中的适当子领域。
