Rai Balwant, Kaur Jasdeep, Jain Rajnish, Anand Suresh C
Oral Imaging center, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium.
Saudi Dent J. 2010 Jul;22(3):129-31. doi: 10.1016/j.sdentj.2010.04.006. Epub 2010 Apr 14.
Matrix metalloproteinases (MMPs), the key enzymes responsible for matrix degradation, are derived from polymorphonuclear leukocytes during the early stages of periodontitis. The aim of this study was planned to determine the levels of GCF (gingival crevicular fluid) matrix metalloproteinase-8 (MMP-8) and metalloproteinase-9 (MMP-9) patients with periodontitis and in healthy controls. Levels of crevicular MMP-8 and -9 were determined by ELISA in subjects with healthy without any periodontal disease (n = 10) and periodontitis (n = 10). Significantly higher crevicular MMP-8 and -9 were observed in cases of periodontitis compared to healthy adults. Crevicular MMP-8 and -9 may serve as biomarkers of periodontal disease and aid in early detection of periodontitis.
基质金属蛋白酶（MMPs）是负责基质降解的关键酶，在牙周炎早期由多形核白细胞产生。本研究旨在测定牙周炎患者和健康对照者龈沟液（GCF）中基质金属蛋白酶-8（MMP-8）和金属蛋白酶-9（MMP-9）的水平。通过酶联免疫吸附测定法（ELISA）测定了无任何牙周疾病的健康受试者（n = 10）和牙周炎患者（n = 10）龈沟中MMP-8和MMP-9的水平。与健康成年人相比，牙周炎患者龈沟中MMP-8和MMP-9水平显著更高。龈沟MMP-8和MMP-9可作为牙周疾病的生物标志物，有助于牙周炎的早期检测。
