Al-Rasheed Abdulaziz
Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Saudi Dent J. 2012 Jan;24(1):17-21. doi: 10.1016/j.sdentj.2011.10.006. Epub 2011 Dec 2.
Many risk factors that might contribute to the pathogenesis of atherosclerosis have been proposed, including chronic inflammation and infection. Furthermore, systemic inflammatory responses to periodontal bacteria have been suggested as a pathogenetic link between periodontal disease and atherosclerosis. The purpose of this study was to estimate the white blood cell (WBC) and platelet counts in chronic periodontitis patients.
Fifty patients with chronic periodontitis and 50 patients with healthy periodontium were included in this study. Oral hygiene status, pocket probing depth (PPD) and clinical attachment level (CAL) were measured. During clinical evaluation, venous blood samples were taken to analyze the WBC and platelet counts. Statistical analysis was utilized to compare differences across groups.
Periodontitis patients demonstrated a significantly higher WBC count (7.22 ± 1.42 × 10(9) cells/L) than that of control patients (5.64 ± 1.56 × 10(9) cells/L; P < 0.001). The platelet count of patients with chronic periodontitis (290.73 ± 56.56 × 10(9) cells/L) was also significantly higher compared to the healthy group (223.37 ± 50.27 × 10(9) cells/L; P < 0.001).
Levels of WBCs and platelets are elevated in periodontitis patients compared to healthy controls.
已提出许多可能导致动脉粥样硬化发病的危险因素，包括慢性炎症和感染。此外，对牙周细菌的全身炎症反应被认为是牙周病与动脉粥样硬化之间的发病联系。本研究的目的是评估慢性牙周炎患者的白细胞（WBC）和血小板计数。
本研究纳入50例慢性牙周炎患者和50例牙周健康患者。测量口腔卫生状况、牙周袋探诊深度（PPD）和临床附着水平（CAL）。在临床评估期间，采集静脉血样以分析WBC和血小板计数。采用统计分析比较各组间的差异。
牙周炎患者的白细胞计数（7.22±1.42×10⁹个细胞/L）显著高于对照组患者（5.64±1.56×10⁹个细胞/L；P<0.001）。慢性牙周炎患者的血小板计数（290.73±56.56×10⁹个细胞/L）也显著高于健康组（223.37±50.27×10⁹个细胞/L；P<0.001）。
与健康对照组相比，牙周炎患者的白细胞和血小板水平升高。
