Department of Pharmacology, PES College of Pharmacy, 50 Feet Road, Hanumanthnagar, Bangalore, Karnataka 560 050, India.
Saudi Pharm J. 2011 Jan;19(1):35-42. doi: 10.1016/j.jsps.2010.10.001. Epub 2010 Oct 31.
The objective of the study is to investigate the alcoholic (AlcE) and aqueous (AqsE) extracts of stem bark of Erythrina indica (Papilionaceae) for hypoglycaemic effects in normal and diabetic rats. Diabetes was induced in rats by a single dose administration of alloxan (120 mg/kg, i.p.) or by injecting dexamethasone (10 mg/kg, i.p.) for 10 days. In normal rats, AlcE and AqsE had significantly decreased the blood glucose level (BGL) in a dose dependent manner after repeated administration for 7 days. In alloxan-induced diabetic rats, both the extracts decreased blood sugar levels with significant improvement in glucose tolerance and body weight at the end of 1st, 2nd and 3rd week after test extract treatment. In case of dexamethasone induced insulin resistant diabetic rats, repeated administration of AlcE and AqsE inhibited the increase in blood glucose level and improved glucose tolerance induced by dexamethasone as compared to dexamethasone induced diabetic rats. These results suggest that both extracts possess hypoglycaemic activity in normal as well as in diabetic rats. Among AlcE and AqsE, AqsE possesses better hypoglycaemic activity than AlcE in all the models. Preliminary phytochemical investigations revealed that alcoholic extracts contain carbohydrates, alkaloids, flavonoids, saponins, phytosterols, phenolics and tannins. Aqueous extract contains carbohydrates, alkaloids, flavonoids, glycosides, phytosterols and triterpenoids. These phytoconstituents may be responsible for the hypoglycaemic activity of the plant.
本研究旨在探讨印度石豆兰（蝶形花科）茎皮的醇提物（AlcE）和水提物（AqsE）对正常和糖尿病大鼠的降血糖作用。通过单次腹腔注射链脲佐菌素（120mg/kg）或连续 10 天腹腔注射地塞米松（10mg/kg）诱导大鼠糖尿病。在正常大鼠中，AlcE 和 AqsE 经重复给药 7 天呈剂量依赖性显著降低血糖水平（BGL）。在链脲佐菌素诱导的糖尿病大鼠中，两种提取物均降低血糖水平，改善葡萄糖耐量，并在测试提取物治疗后第 1、2 和 3 周结束时体重显著增加。在地塞米松诱导的胰岛素抵抗型糖尿病大鼠中，与地塞米松诱导的糖尿病大鼠相比，AlcE 和 AqsE 的重复给药抑制了地塞米松引起的血糖水平升高和葡萄糖耐量改善。这些结果表明，两种提取物均具有正常大鼠和糖尿病大鼠的降血糖活性。在 AlcE 和 AqsE 中，AqsE 在所有模型中均比 AlcE 具有更好的降血糖活性。初步的植物化学研究表明，醇提物含有碳水化合物、生物碱、类黄酮、皂苷、植物甾醇、酚类和单宁。水提物含有碳水化合物、生物碱、类黄酮、糖苷、植物甾醇和三萜类化合物。这些植物成分可能是该植物具有降血糖活性的原因。
