Department of Pharmaceutical Technology, Y.B. Chavan College of Pharmacy, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India.
Saudi Pharm J. 2011 Apr;19(2):85-93. doi: 10.1016/j.jsps.2011.01.004. Epub 2011 Jan 18.
Study objectives were to develop a unique floating ring capsule dosage form which combines gastric soluble and insoluble portions, and to evaluate its suitability for stomach specific drug delivery. New floating ring capsules were developed using different polymers and were compared for various parameters. The formulation with HPMC and sodium CMC has better floating properties. The effects of polymers concentration on drug release were studies by in vitro release studies. The interaction studies of combined drug with polymers were determined using FT-IR spectroscopy. The entrapped air within the gel barrier and lower densities of HPMC and sodium CMC resulted in better floating behavior. Steady slow gel formations showed prolonged drug release. The in vitro release rates were generally found to be faster with low concentration of carbopol showing release within 2 h, while formulations containing high amount of HPMC showed release in 8 h. In particular, the higher concentration of HPMC formulation shows the best drug release performance. A very low change in peak shift was observed only with sodium alginate formulations. Further, FT-IR measurements confirmed the absence of any chemical interactions. Results indicate that new floating ring capsule is a promise dosage form for stomach specific delivery.
研究目的是开发一种独特的漂浮环胶囊剂型，将胃溶性和不溶性部分结合在一起，并评估其用于胃特定药物输送的适用性。使用不同的聚合物开发了新的漂浮环胶囊，并对其各种参数进行了比较。HPMC 和羧甲基纤维素钠的配方具有更好的漂浮性能。通过体外释放研究研究了聚合物浓度对药物释放的影响。使用傅里叶变换红外光谱法确定了组合药物与聚合物的相互作用研究。凝胶屏障内夹带的空气和 HPMC 和羧甲基纤维素钠的较低密度导致更好的漂浮行为。稳定的缓慢凝胶形成显示出延长的药物释放。通常发现低浓度的卡波姆具有更快的体外释放率，在 2 小时内释放，而含有高浓度 HPMC 的制剂则在 8 小时内释放。特别是，HPMC 浓度较高的制剂显示出最佳的药物释放性能。仅用海藻酸钠制剂观察到峰位移的变化非常小。此外，傅里叶变换红外测量证实不存在任何化学相互作用。结果表明，新型漂浮环胶囊是一种有前途的胃特定给药剂型。
