Ayachit Guruprasad S, Pandey Neeraj, Dwivedi Vandana
M.M. Joshi Eye Institute, Hubli 580 021, India.
Saudi J Ophthalmol. 2011 Apr;25(2):199-202. doi: 10.1016/j.sjopt.2010.11.005. Epub 2010 Nov 13.
Twenty-seven years old healthy woman presented with complaints of sudden painless blurred vision in right eye for 1 week. On examination, visual acuity was 20/30 in the right eye and 20/20 in left eye. Fundus examination OS was normal; OD demonstrated a flat, opaque, yellowish parapapillary choroidal lesion with grayish membrane associated with minimal subretinal fluid suggestive of a CNVM in the center. B-scan ultrasonography revealed findings consistent with a choroidal osteoma. Fundus fluorescein angiography of the right eye revealed a relatively well-defined area of hyperfluorescence that increased in size and intensity in the later phases suggestive of active extrafoveal CNVM. Optical coherence tomography confirmed the extrafoveal CNVM with subfoveal fluid. She was treated with intravitreal Bevacizumab OD. At the 2 weeks visit, vision OD improved to 20/20. The FFA and OCT revealed a resolved CNVM. Intravitreal Bevacizumab may be an effective alternative in the management of CNVM secondary to choroidal osteoma.
一名27岁健康女性因右眼突发无痛性视力模糊1周前来就诊。检查发现,右眼视力为20/30,左眼视力为20/20。左眼眼底检查正常;右眼可见一个扁平、不透明、淡黄色的视乳头旁脉络膜病变,伴有灰白色膜,中央有少量视网膜下液,提示中心性脉络膜新生血管(CNVM)。B超检查结果与脉络膜骨瘤相符。右眼眼底荧光血管造影显示一个相对边界清晰的高荧光区域,在后期阶段大小和强度增加,提示活跃的黄斑外CNVM。光学相干断层扫描证实了黄斑外CNVM伴黄斑下液。右眼给予玻璃体内注射贝伐单抗治疗。在2周的随访中,右眼视力提高到20/20。荧光血管造影(FFA)和光学相干断层扫描(OCT)显示CNVM已消退。玻璃体内注射贝伐单抗可能是治疗脉络膜骨瘤继发CNVM的有效替代方法。