HIV-1 感染男性中抗 CMV IgG 水平的病毒学相关因素。
Virologic correlates of anti-CMV IgG levels in HIV-1-infected men.
机构信息
University of California-San Diego, La Jolla.
出版信息
J Infect Dis. 2014 Feb 1;209(3):452-6. doi: 10.1093/infdis/jit434. Epub 2013 Aug 20.
Abstract
In human immunodeficiency virus (HIV)-infected individuals, higher levels of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) antibody have been associated with increased immune activation, increased HIV transmission, cardiovascular complications, and neurocognitive impairment. However, the mechanism of these observations is unknown. This analysis of 228 HIV-infected men found that higher CMV IgG levels were positively associated with older age and antiretroviral treatment. Higher frequency of detectable CMV in peripheral blood mononuclear cells and recurrent seminal CMV reactivations were associated with lower plasma CMV IgG levels, suggesting that immune response to CMV rather than direct effect of viral replication is likely responsible for adverse clinical outcome observed in other studies.
摘要
在人类免疫缺陷病毒（HIV）感染者中，较高水平的抗巨细胞病毒（CMV）免疫球蛋白 G（IgG）抗体与免疫激活增加、HIV 传播增加、心血管并发症和神经认知障碍有关。然而，这些观察结果的机制尚不清楚。这项对 228 名 HIV 感染男性的分析发现，较高的 CMV IgG 水平与年龄较大和抗逆转录病毒治疗有关。外周血单核细胞中可检测到的 CMV 频率较高和反复出现的精液 CMV 再激活与较低的血浆 CMV IgG 水平相关，这表明对 CMV 的免疫反应而不是病毒复制的直接影响可能是导致其他研究中观察到不良临床结局的原因。
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