School of Health Sciences and Health Innovations Research Institute, RMIT University Melbourne, VIC, Australia.
Front Neurosci. 2013 Aug 12;7:144. doi: 10.3389/fnins.2013.00144. eCollection 2013.
Our early life nutritional environment can influence several aspects of physiology, including our propensity to become obese. There is now evidence to suggest perinatal diet can also independently influence development of our innate immune system. This review will address three not-necessarily-exclusive mechanisms by which perinatal nutrition can program neuroimmune function long-term: by predisposing the individual to obesity, by altering the gut microbiota, and by inducing epigenetic modifications that alter gene transcription throughout life.
我们早期的营养环境会影响生理的多个方面，包括肥胖的倾向。现在有证据表明，围产期饮食也可以独立影响先天免疫系统的发育。这篇综述将讨论围产期营养长期编程神经免疫功能的三个并非完全排他的机制：使个体易患肥胖、改变肠道微生物群，以及诱导改变一生中基因转录的表观遗传修饰。
