School of Food Science and Biotechnology, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 702-701, Korea.
Nutr Res Pract. 2013 Aug;7(4):262-6. doi: 10.4162/nrp.2013.7.4.262. Epub 2013 Aug 7.
Certain phenolic compounds are known to exhibit laxative properties. Seed sprouts, such as those of peanut, are known to promote de novo biosynthesis of phenolic compounds. This study was conducted to examine the potential laxative properties of 80% (v/v) ethanolic extract of peanut sprout (PSE), which contains a high concentration of phenolic compounds such as resveratrol. For this, SD rats were orally administered PSE while a control group was incubated with saline. Laxative effects were examined in both groups of rats. Constipation induced by loperamide in SD rats was improved by administration of PSE. Constipated rats showed increased intestinal movement of BaSO4 upon administration of PSE compared to the control, and the groups administered 100 or 1,000 mg PSE/kg bw were not significantly different in transit time of the indicator. However, colon length was not statistically different among the experimental groups, although it was longer in the group incubated with 1 g PSE/kg bw compared to other groups. Further, there was no significant difference in stool number among the experimental groups. Taken together, these findings show that PSE has a laxative effect in a rat model of loperamide-induced constipation.
某些酚类化合物具有通便作用。众所周知，种子芽，如花生芽，能够促进酚类化合物的从头生物合成。本研究旨在检测花生芽 80%（v/v）乙醇提取物（PSE）的潜在通便作用，PSE 中含有高浓度的酚类化合物，如白藜芦醇。为此，SD 大鼠经口给予 PSE，而对照组给予生理盐水。在两组大鼠中检查通便作用。PSE 可改善洛哌丁胺诱导的 SD 大鼠便秘。与对照组相比，给予 PSE 的便秘大鼠的 BaSO4 肠道运动增加，给予 100 或 1000mg PSE/kg bw 的组在指示剂的转运时间上无显著差异。然而，实验组之间的结肠长度无统计学差异，尽管与其他组相比，给予 1g PSE/kg bw 的组的结肠长度更长。此外，实验组之间的粪便数量无显著差异。综上所述，这些发现表明 PSE 在洛哌丁胺诱导的便秘大鼠模型中具有通便作用。
