• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

光动力疗法治疗不可切除的胆管癌：不适合犹豫不决者。

Photodynamic therapy in unresectable cholangiocarcinoma: not for the uncommitted.

作者信息

Talreja Jayant P, Degaetani Marisa, Ellen Kristi, Schmitt Timothy, Gaidhane Monica, Kahaleh Michel

机构信息

Department of Gastroenterology and Hepatology, University of Virginia School of Medicine, Charlottesville, VA, USA.

出版信息

Clin Endosc. 2013 Jul;46(4):390-4. doi: 10.5946/ce.2013.46.4.390. Epub 2013 Jul 31.

DOI:10.5946/ce.2013.46.4.390
PMID:23964337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3746145/
Abstract

BACKGROUND/AIMS: Photodynamic therapy (PDT) in unresectable cholangiocarcinoma has been associated with improved survival. We report a single tertiary care center experience over the past 6 years.

METHODS

Fifty-five patients with unresectable cholangiocarcinoma received PDT between 2004 and 2010. Plastic stents were placed after PDT to prevent cholangitis.

RESULTS

Twenty-seven patients (49%) showed Bismuth type IV, 22 (41%) showed Bismuth type III, and six (10%) showed Bismuth type I and II. Twenty patients (37%) received chemotherapy and radiation therapy, five (9%) received chemotherapy only; and one (2%) received radiation therapy only. Mean number of PDT sessions was 1.9±1.5 sessions (range, 1 to 9). Mean survival duration was 293±266 days (median, 190; range, 25 to 1,332). PDT related complications included three (5%) facial burn, three (5%) photosensitivity, and two (3%) rash. Kaplan-Meier analysis comparing the survival means of patients who received PDT and chemotherapy/radiation therapy (median survival 257 days; 95% confidence interval [CI], 166 to 528) versus who received PDT only (median survival 183 days; 95% CI, 129 to 224) showed no significant difference (log-rank p=0.20).

CONCLUSIONS

PDT has a measurable impact on survival in unresectable cholangiocarcinoma but requires aggressive stenting posttherapy.

摘要

背景/目的：光动力疗法（PDT）应用于不可切除的胆管癌可提高患者生存率。我们报告了过去6年在一家三级医疗中心的经验。

方法

2004年至2010年间，55例不可切除的胆管癌患者接受了PDT治疗。PDT治疗后放置塑料支架以预防胆管炎。

结果

27例（49%）为Bismuth IV型，22例（41%）为Bismuth III型，6例（10%）为Bismuth I型和II型。20例（37%）患者接受了化疗和放疗，5例（9%）仅接受化疗，1例（2%）仅接受放疗。PDT治疗的平均次数为1.9±1.5次（范围1至9次）。平均生存时间为293±266天（中位数190天；范围25至1332天）。PDT相关并发症包括3例（5%）面部灼伤、3例（5%）光敏反应和2例（3%）皮疹。Kaplan-Meier分析比较接受PDT联合化疗/放疗患者（中位生存期257天；95%置信区间[CI]，166至528）与仅接受PDT患者（中位生存期183天；95%CI，129至224）的生存均值，结果显示无显著差异（对数秩检验p=0.20）。

结论

PDT对不可切除胆管癌患者的生存有显著影响，但治疗后需要积极放置支架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/eaccc2ab07a6/ce-46-390-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/57504edc5fd4/ce-46-390-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/518284da35c2/ce-46-390-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/a7cf8817893b/ce-46-390-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/eaccc2ab07a6/ce-46-390-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/57504edc5fd4/ce-46-390-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/518284da35c2/ce-46-390-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/a7cf8817893b/ce-46-390-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0c/3746145/eaccc2ab07a6/ce-46-390-g004.jpg

相似文献

1
Photodynamic therapy in unresectable cholangiocarcinoma: not for the uncommitted.光动力疗法治疗不可切除的胆管癌：不适合犹豫不决者。
Clin Endosc. 2013 Jul;46(4):390-4. doi: 10.5946/ce.2013.46.4.390. Epub 2013 Jul 31.
2
Unresectable cholangiocarcinoma: comparison of survival in biliary stenting alone versus stenting with photodynamic therapy.不可切除的胆管癌：单纯胆道支架置入与支架置入联合光动力治疗的生存比较。
Clin Gastroenterol Hepatol. 2008 Mar;6(3):290-7. doi: 10.1016/j.cgh.2007.12.004. Epub 2008 Feb 6.
3
ERCP-directed radiofrequency ablation and photodynamic therapy are associated with comparable survival in the treatment of unresectable cholangiocarcinoma.内镜逆行胰胆管造影（ERCP）引导下的射频消融术和光动力疗法在不可切除胆管癌的治疗中具有相似的生存率。
Gastrointest Endosc. 2014 Nov;80(5):794-804. doi: 10.1016/j.gie.2014.02.1030. Epub 2014 May 15.
4
Factors associated with increased survival after photodynamic therapy for cholangiocarcinoma.胆管癌光动力治疗后生存时间延长的相关因素。
Clin Gastroenterol Hepatol. 2007 Jun;5(6):743-8. doi: 10.1016/j.cgh.2007.02.021.
5
Randomised phase II trial of photodynamic therapy plus oral fluoropyrimidine, S-1, versus photodynamic therapy alone for unresectable hilar cholangiocarcinoma.随机Ⅱ期临床试验：光动力疗法联合口服氟嘧啶（S-1）对比单纯光动力疗法治疗不可切除肝门部胆管癌。
Eur J Cancer. 2014 May;50(7):1259-68. doi: 10.1016/j.ejca.2014.01.008. Epub 2014 Jan 30.
6
Photodynamic therapy for unresectable cholangiocarcinoma: contribution of single operator cholangioscopy for targeted treatment.不可切除的胆管癌的光动力疗法：单操作员胆管镜检查在靶向治疗中的作用。
Photochem Photobiol Sci. 2011 Jul;10(7):1233-8. doi: 10.1039/c0pp00259c. Epub 2011 Apr 21.
7
Photodynamic therapy prolongs metal stent patency in patients with unresectable hilar cholangiocarcinoma.光动力疗法可延长不可切除肝门部胆管癌患者金属支架通畅时间。
World J Gastroenterol. 2012 Oct 21;18(39):5589-94. doi: 10.3748/wjg.v18.i39.5589.
8
Feasibility and safety of long-term photodynamic therapy (PDT) in the palliative treatment of patients with hilar cholangiocarcinoma.经 PDT 姑息治疗肝门部胆管癌的长期可行性和安全性研究。
Eur J Med Res. 2011 Sep 12;16(9):391-5. doi: 10.1186/2047-783x-16-9-391.
9
Biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma with jaundice.对于伴有黄疸的不可切除的胆管癌，采用胆汁引流、光动力疗法和化疗。
J Gastroenterol Hepatol. 2009 Nov;24(11):1745-52. doi: 10.1111/j.1440-1746.2009.05915.x. Epub 2009 Sep 25.
10
Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma.评估内镜下光动力疗法治疗晚期胆管癌后患者预后的初步研究。
J Gastroenterol Hepatol. 2005 Mar;20(3):415-20. doi: 10.1111/j.1440-1746.2005.03582.x.

引用本文的文献

1
Ablative Therapy in Non-HCC Liver Malignancy.非肝细胞癌肝脏恶性肿瘤的消融治疗
Cancers (Basel). 2023 Feb 14;15(4):1200. doi: 10.3390/cancers15041200.
2
Endoscopic palliation of malignant biliary obstruction.恶性胆管梗阻的内镜下姑息治疗
World J Gastrointest Endosc. 2022 Oct 16;14(10):581-596. doi: 10.4253/wjge.v14.i10.581.
3
Comparing palliative treatment options for cholangiocarcinoma: photodynamic therapy vs. radiofrequency ablation.胆管癌姑息治疗方案比较：光动力疗法与射频消融术

本文引用的文献

1
Photodynamic therapy for unresectable cholangiocarcinoma: contribution of single operator cholangioscopy for targeted treatment.不可切除的胆管癌的光动力疗法：单操作员胆管镜检查在靶向治疗中的作用。
Photochem Photobiol Sci. 2011 Jul;10(7):1233-8. doi: 10.1039/c0pp00259c. Epub 2011 Apr 21.
2
Clinical feasibility of direct peroral cholangioscopy-guided photodynamic therapy for inoperable cholangiocarcinoma performed by using an ultra-slim upper endoscope (with videos).经超微内镜行直接经口胆胰管镜引导光动力疗法治疗不可切除的胆管癌的临床可行性（附视频）
Gastrointest Endosc. 2011 Apr;73(4):808-13. doi: 10.1016/j.gie.2010.11.049. Epub 2011 Feb 12.
3
Clin Endosc. 2022 May;55(3):347-354. doi: 10.5946/ce.2021.274. Epub 2022 May 17.
4
Ablative therapies of the biliary tree.胆道的消融治疗。
Transl Gastroenterol Hepatol. 2021 Oct 25;6:63. doi: 10.21037/tgh.2020.02.03. eCollection 2021.
5
Chlorin A-mediated photodynamic therapy induced apoptosis in human cholangiocarcinoma cells via impaired autophagy flux.二氢卟吩A介导的光动力疗法通过损害自噬通量诱导人胆管癌细胞凋亡。
Am J Transl Res. 2020 Sep 15;12(9):5080-5094. eCollection 2020.
6
Endoscopic palliation of malignant biliary strictures.恶性胆管狭窄的内镜下姑息治疗
World J Gastrointest Oncol. 2016 Mar 15;8(3):240-7. doi: 10.4251/wjgo.v8.i3.240.
7
Photodynamic Therapy Plus Chemotherapy Compared with Photodynamic Therapy Alone in Hilar Nonresectable Cholangiocarcinoma.光动力疗法联合化疗与单纯光动力疗法治疗肝门部不可切除胆管癌的比较
Gut Liver. 2016 May 23;10(3):470-5. doi: 10.5009/gnl15175.
8
Is There Any Evidence for a Role of Local Treatment in Cholangiocarcinoma?是否有证据表明局部治疗在胆管癌中起作用？
Viszeralmedizin. 2014 Aug;30(4):254-60. doi: 10.1159/000365312.
9
Impact of Radiofrequency Ablation on Malignant Biliary Strictures: Results of a Collaborative Registry.射频消融对恶性胆管狭窄的影响：一项合作登记研究的结果
Dig Dis Sci. 2015 Jul;60(7):2164-9. doi: 10.1007/s10620-015-3558-3. Epub 2015 Feb 21.
The role of photodynamic therapy for hilar cholangiocarcinoma.
光动力疗法在肝门部胆管癌中的作用。
Korean J Intern Med. 2010 Dec;25(4):345-52. doi: 10.3904/kjim.2010.25.4.345. Epub 2010 Nov 27.
4
R0 but not R1/R2 resection is associated with better survival than palliative photodynamic therapy in biliary tract cancer.R0 切除术而非 R1/R2 切除术与胆道癌患者的生存改善相关，优于姑息性光动力疗法。
Liver Int. 2011 Jan;31(1):99-107. doi: 10.1111/j.1478-3231.2010.02345.x. Epub 2010 Sep 16.
5
Photodynamic therapy is associated with an improvement in survival in patients with irresectable hilar cholangiocarcinoma.光动力疗法与不可切除的肝门部胆管癌患者的生存改善相关。
HPB (Oxford). 2009 Nov;11(7):570-7. doi: 10.1111/j.1477-2574.2009.00102.x.
6
Biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma with jaundice.对于伴有黄疸的不可切除的胆管癌，采用胆汁引流、光动力疗法和化疗。
J Gastroenterol Hepatol. 2009 Nov;24(11):1745-52. doi: 10.1111/j.1440-1746.2009.05915.x. Epub 2009 Sep 25.
7
Systematic review: photodynamic therapy for unresectable cholangiocarcinoma.系统评价：光动力疗法治疗不可切除的胆管癌。
J Hepatobiliary Pancreat Sci. 2010 Mar;17(2):125-31. doi: 10.1007/s00534-009-0109-3. Epub 2009 May 20.
8
Management of pancreaticobiliary disease using a new intra-ductal endoscope: the Texas experience.使用新型导管内内窥镜治疗胰胆疾病：德克萨斯州的经验。
World J Gastroenterol. 2009 Mar 21;15(11):1353-8. doi: 10.3748/wjg.15.1353.
9
Photodynamic therapy of cholangiocarcinoma.光动力疗法治疗胆管癌。
HPB (Oxford). 2008;10(3):161-3. doi: 10.1080/13651820801992625.
10
Intraductal biliary and pancreatic endoscopy: an expanding scope of possibility.胆管和胰管内内镜检查：可能性不断扩大的领域。
World J Gastroenterol. 2008 May 28;14(20):3129-36. doi: 10.3748/wjg.14.3129.