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香蕉皮提取物的抗炎和抗氧化活性

Anti-inflammatory and antioxidant activities of extracts from Musa sapientum peel.

作者信息

Phuaklee Pathompong, Ruangnoo Srisopa, Itharat Arunporn

机构信息

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.

出版信息

J Med Assoc Thai. 2012 Jan;95 Suppl 1:S142-6.

PMID:23964457
Abstract

BACKGROUND

Many parts of Musa sapientum Linn. (Musaceae) are used in Thai traditional medicine as drugs, food supplements and cosmetics. The banana peel is used as an astringent in foot care, the unripe fruit is used to treat diarrhea and, the ripe fruit is used as tonic.

OBJECTIVE

To evaluate anti-inflammatory and antioxidant activities of banana peel extracts obtained from different extraction methods and to determine their total phenolic content.

MATERIAL AND METHOD

Four extraction methods were used to extract unripe and ripe peels. Nitric oxide inhibitory and DPPH scavenging assays were used to evaluate anti-inflammatory and antioxidant activities, respectively. Folin-Ciocalteu's reagent was used to determine total phenolic content.

RESULTS

The water extract of fresh ripe peel exhibited the most potent NO inhibitory activity (IC50 = 6.68 +/- 0.34 microg/ml), but apparently exhibited no antioxidant activity. The decoction extract of fresh unripe peel exhibited strong antioxidant activity as well as had the highest total phenolic compound. The antioxidant activity exhibited a correlation with the total phenolic content.

CONCLUSION

This study supports the use of Musa sapientum peel in Thai Traditional Medicine for treatment of inflammatory-related diseases.

摘要

背景

香蕉(芭蕉科,香蕉属)的许多部位在泰国传统医学中用作药物、食品补充剂和化妆品。香蕉皮在足部护理中用作收敛剂,未成熟果实用于治疗腹泻,成熟果实用作滋补品。

目的

评估不同提取方法获得的香蕉皮提取物的抗炎和抗氧化活性,并测定其总酚含量。

材料与方法

采用四种提取方法提取未成熟和成熟的香蕉皮。分别采用一氧化氮抑制试验和DPPH清除试验评估抗炎和抗氧化活性。使用福林-酚试剂测定总酚含量。

结果

新鲜成熟香蕉皮的水提取物表现出最强的一氧化氮抑制活性(IC50 = 6.68 +/- 0.34微克/毫升),但显然没有抗氧化活性。新鲜未成熟香蕉皮的水煎提取物表现出较强的抗氧化活性,且总酚化合物含量最高。抗氧化活性与总酚含量呈正相关。

结论

本研究支持泰国传统医学中使用香蕉皮治疗炎症相关疾病。

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