Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster , Corrensstraße 48, D-48149 Münster, Germany.
J Med Chem. 2013 Dec 27;56(24):9809-19. doi: 10.1021/jm400660u. Epub 2013 Sep 10.
The exact 3D structure of the enigmatic σ1 receptor is unknown, as the crystal structure of this protein has not been solved so far. Many efforts have been devoted to unveiling the structure of the σ1 receptor and specifically its binding site, which include photoaffinity labeling, site directed mutagenesis, and homology modeling. The aim of the present miniperspective is to give a short overview of all results that contribute to the current knowledge of the σ1 receptor and its ligand binding site.
神秘的 σ1 受体的确切 3D 结构尚不清楚，因为迄今为止该蛋白质的晶体结构尚未解决。人们做出了许多努力来揭示 σ1 受体的结构，特别是其结合位点，包括光亲和标记、定点诱变和同源建模。本文的目的是简要概述所有有助于当前对 σ1 受体及其配体结合位点的了解的结果。
