动物肾脏生理和疾病模型。
Animal Models of Renal Pathophysiology and Disease.
机构信息
1st Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Working Group Integrative Kidney Physiology, Institute of Physiology, Charité-University Medicine Berlin, Berlin, Germany.
出版信息
Methods Mol Biol. 2021;2216:27-44. doi: 10.1007/978-1-0716-0978-1_2.
Abstract
Renal diseases remain devastating illnesses with unacceptably high rates of mortality and morbidity worldwide. Animal models are essential tools to better understand the pathomechanisms of kidney-related illnesses and to develop new, successful therapeutic strategies. Magnetic resonance imaging (MRI) has been actively explored in the last decades for assessing renal function, perfusion, tissue oxygenation as well as the degree of fibrosis and inflammation. This chapter aims to provide a comprehensive overview of animal models of acute and chronic kidney diseases, highlighting MRI-specific considerations, advantages, and pitfalls, and thus assisting the researcher in experiment planning.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.
摘要
肾脏疾病仍然是一种具有高死亡率和发病率的毁灭性疾病，在全球范围内都是如此。动物模型是更好地了解与肾脏相关疾病的病理机制和开发新的、成功的治疗策略的重要工具。在过去的几十年中，磁共振成像（MRI）一直被积极用于评估肾功能、灌注、组织氧合以及纤维化和炎症程度。本章旨在全面概述急性和慢性肾脏疾病的动物模型，重点介绍 MRI 的具体注意事项、优点和缺陷，从而帮助研究人员进行实验设计。本出版物基于 COST 行动 PARENCHIMA 的工作，这是一个由社区驱动的网络，由欧盟科学技术合作组织（COST）计划资助，旨在提高肾脏 MRI 生物标志物的重现性和标准化。
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2
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Transpl Int. 2018 Nov;31(11):1268-1278. doi: 10.1111/tri.13293. Epub 2018 Jul 4.
3
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Clin Exp Nephrol. 2018 Aug;22(4):752-763. doi: 10.1007/s10157-018-1552-8. Epub 2018 Mar 20.
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