Duan Xiao-Yan, Jia Fei-Yong, Jiang Hui-Yi
Department of Pediatric Neurological Rehabilitation, First Hospital of Jilin University, Changchun 130031, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2013 Aug;15(8):698-702.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with multiple genetic and environmental risk factors. The interplay between genetic and environmental factors has become the subject of intensified research in the last several years. Vitamin D deficiency has recently been proposed as a possible environmental risk factor for ASD. Vitamin D has a unique role in brain homeostasis, embryogenesis and neurodevelopment, immunological modulation (including the brain's immune system), antioxidation, antiapoptosis, neural differentiation and gene regulation. Children with ASD had significantly lower serum levels of 25-hydroxy vitamin D than healthy children.Therefore vitamin D deficiency during pregnancy and early childhood may be an environmental trigger for ASD.
自闭症谱系障碍（ASD）是一种复杂的神经发育障碍，存在多种遗传和环境风险因素。在过去几年中，遗传因素与环境因素之间的相互作用已成为深入研究的主题。最近有人提出维生素D缺乏可能是ASD的一种环境风险因素。维生素D在脑内稳态、胚胎发育和神经发育、免疫调节（包括大脑的免疫系统）、抗氧化、抗细胞凋亡、神经分化和基因调控方面具有独特作用。与健康儿童相比，ASD患儿血清25-羟维生素D水平显著更低。因此，孕期和幼儿期维生素D缺乏可能是ASD的一种环境触发因素。
