Wang Tiantian, Shan Ling, Du Lin, Feng Junyan, Xu Zhida, Staal Wouter G, Jia Feiyong
Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Eur Child Adolesc Psychiatry. 2016 Apr;25(4):341-50. doi: 10.1007/s00787-015-0786-1. Epub 2015 Oct 29.
Vitamin D may play an important role in the etiology of Autism Spectrum Disorders (ASD). Vitamin D is regarded as a neuroactive steroid affecting brain development and function. It plays an essential role in myelination, which is important for connectivity in the brain. Studies have shown that decreased vitamin D levels in patients, decreased maternal vitamin D levels during pregnancy, and decreased exposure to solar UVB might increase the risk for ASD. In addition, autism symptoms and global functioning may improve after vitamin D supplementation. Here, we sought to aggregate information from previous publications on vitamin D levels and ASD, in order to achieve a higher statistical power and thereby to determine the validity of vitamin D deficiency as a risk factor for ASD. For this meta-analysis, 11 studies met the inclusion and exclusion criteria, accounting for a total of 870 ASD patients and 782 healthy controls. Levels of serum 25(OH) D in participants with ASD were significantly lower than controls, suggesting that lower vitamin D level might be a risk factor for ASD.
维生素D可能在自闭症谱系障碍（ASD）的病因学中发挥重要作用。维生素D被视为一种影响大脑发育和功能的神经活性类固醇。它在髓鞘形成中起着至关重要的作用，而髓鞘形成对大脑的连通性很重要。研究表明，患者体内维生素D水平降低、孕期母亲维生素D水平降低以及太阳紫外线B暴露减少可能会增加患ASD的风险。此外，补充维生素D后，自闭症症状和整体功能可能会改善。在此，我们试图汇总先前关于维生素D水平与ASD的出版物中的信息，以获得更高的统计效力，从而确定维生素D缺乏作为ASD风险因素的有效性。对于这项荟萃分析，11项研究符合纳入和排除标准，共计870名ASD患者和782名健康对照。ASD参与者的血清25(OH)D水平显著低于对照组，这表明较低的维生素D水平可能是ASD的一个风险因素。
